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  1. This study aimed to determine whether ultra-low tidal volume ventilation (ULTVV) applied during cardiopulmonary resuscitation (CPR) compared with standard ventilation (intermittent positive pressure ventilatio...

    Authors: Katja Mohnke, Philipp Conzelmann, Miriam Renz, Julian Riedel, René Rissel, Andrea Urmann, Johanna Hain, Bastian Duenges, Alexander Ziebart and Robert Ruemmler
    Citation: Intensive Care Medicine Experimental 2023 11:81
  2. Venous blood gas sampling has replaced arterial sampling in many critically ill patients, though interpretation of venous pCO2 still remains a challenge. Lemoël et al., Farkas and Zeserson et al. have proposed mo...

    Authors: Matthias Jörg, Malin Öster, Jens Wretborn and Daniel B. Wilhelms
    Citation: Intensive Care Medicine Experimental 2023 11:80
  3. Currently, most patients with cardiac arrest (CA) show reversible myocardial dysfunction, hemodynamic instability, systemic inflammation and other pathophysiological state in early stage of resuscitation, some...

    Authors: Tianfeng Hua, Yuqian Chu, Minjie Wang, Yijun Zhang, Wei Shi, Qihui Huang, Liangliang Zhang and Min Yang
    Citation: Intensive Care Medicine Experimental 2023 11:78
  4. Extracorporeal life support (ECLS) for acute respiratory failure encompasses veno-venous extracorporeal membrane oxygenation (V-V ECMO) and extracorporeal carbon dioxide removal (ECCO2R). V-V ECMO is primarily us...

    Authors: Tommaso Tonetti, Alberto Zanella, David Pérez-Torres, Giacomo Grasselli and V. Marco Ranieri
    Citation: Intensive Care Medicine Experimental 2023 11:77
  5. Trauma patients frequently receive supplemental oxygen, but its hemodynamic effects in blood loss are poorly understood. We studied the effects of oxygen on the hemodynamic response and tolerance to simulated ...

    Authors: Sole Lindvåg Lie, Jonny Hisdal, Marius Rehn and Lars Øivind Høiseth
    Citation: Intensive Care Medicine Experimental 2023 11:76
  6. Ventilation during cardiopulmonary resuscitation (CPR) has long been a part of the standard treatment during cardiac arrests. Ventilation is usually given either during continuous chest compressions (CCC) or d...

    Authors: Johan Mälberg, Silvia Marchesi, Douglas Spangler, Nermin Hadziosmanovic, David Smekal and Sten Rubertsson
    Citation: Intensive Care Medicine Experimental 2023 11:75
  7. There is a need to monitor tidal volume in critically ill patients with acute respiratory failure, given its relation with adverse clinical outcome. However, quantification of tidal volume in non-intubated pat...

    Authors: Matthijs L. Janssen, Annemijn H. Jonkman, Myrte Wennen, Evert-Jan Wils, Henrik Endeman and Leo Heunks
    Citation: Intensive Care Medicine Experimental 2023 11:73
  8. Neurological manifestations of severe coronavirus infections, including SARS-CoV-2, are wide-ranging and may persist following virus clearance. Detailed understanding of the underlying changes in brain functio...

    Authors: Salil R. Rajayer and Stephen M. Smith
    Citation: Intensive Care Medicine Experimental 2023 11:71
  9. Sepsis is characterized by highly heterogeneous immune responses associated with a spectrum of disease severity. Methods that rapidly and sensitively profile these immune responses can potentially personalize ...

    Authors: Anthony S. Bonavia, Abigail Samuelsen, Menglu Liang, Jodi Hanson, Daniel McKeone, Zissis C. Chroneos and E. Scott Halstead
    Citation: Intensive Care Medicine Experimental 2023 11:70
  10. A prompt and effective immune response is required for clearance of pathogens but exaggerated states of inflammation can cause extensive collateral damage to the host. We have previously used a rapid near-pati...

    Authors: Nazlıhan Boyacı Dündar, David Sarphie, Kenan Yüce, Ümmügülsüm Gaygısız, O. Tolga Kaskatı, Melda Türkoğlu, Gülbin Aygencel Bıkmaz, Lale Karabıyık, Kayhan Çağlar, Gülendam Bozdayı, Rubina Mian, Paul Moss and Mustafa Necmi İlhan
    Citation: Intensive Care Medicine Experimental 2023 11:69
  11. The understanding of high mortality associated with intra-abdominal candidiasis (IAC) remains limited. While Candida is considered a harmless colonizer in the digestive tract, its role as a true pathogen in IAC i...

    Authors: Emmanuel Novy, Mathieu Esposito, Julien Birckener, Adeline Germain, Marie-Reine Losser, Marie-Claire Machouart and Philippe Guerci
    Citation: Intensive Care Medicine Experimental 2023 11:67
  12. Neurofilament light chain (NfL), glial fibrillary acidic protein (GFAP), and total-tau protein (tau) are novel blood biomarkers of neurological injury, and may be used to predict outcomes in critical COVID-19.

    Authors: Theodor Sievert, Ingrid Didriksson, Martin Spångfors, Gisela Lilja, Kaj Blennow, Henrik Zetterberg, Attila Frigyesi and Hans Friberg
    Citation: Intensive Care Medicine Experimental 2023 11:66
  13. Trunk inclination from semirecumbent head-upright to supine-flat positioning reduces driving pressure and increases respiratory system compliance in patients with acute respiratory distress syndrome (ARDS). Th...

    Authors: Martín H. Benites, David Torres, Fabian Poblete, Francisco Labbe, María C. Bachmann, Tomas E. Regueira, Leonardo Soto, Andrés Ferre, Jorge Dreyse and Jaime Retamal
    Citation: Intensive Care Medicine Experimental 2023 11:65

    The Correspondence to this article has been published in Intensive Care Medicine Experimental 2023 11:90

    The Editorial to this article has been published in Intensive Care Medicine Experimental 2023 11:79

  14. Sepsis is a condition with high morbidity and mortality. Prompt recognition and initiation of treatment is essential. Despite forming an integral part of sepsis management, fluid resuscitation may also lead to...

    Authors: Annelie Barrueta Tenhunen, Jaap van der Heijden, Paul Skorup, Marco Maccarana, Anders Larsson, Anders Larsson, Gaetano Perchiazzi and Jyrki Tenhunen
    Citation: Intensive Care Medicine Experimental 2023 11:63
  15. Endothelial injury and permeability are a hallmark of sepsis. Initial resuscitation of septic patients with crystalloids is associated with aggravation of endothelial permeability, which may be related either ...

    Authors: Daan P. van den Brink, Derek J. B. Kleinveld, Annabel Bongers, Jaël Vos, Joris J. T. H. Roelofs, Nina C. Weber, Jaap D. van Buul and Nicole P. Juffermans
    Citation: Intensive Care Medicine Experimental 2023 11:62
  16. Patients undergoing high-risk surgery show haemodynamic instability and an increased risk of morbidity. However, most of the available data concentrate on the intraoperative period. This study aims to characte...

    Authors: Charlotte Middel, Matthias Stetzuhn, Nadine Sander, Björn Kalkbrenner, Timo Tigges, Alexandru-Gabriel Pielmus, Claudia Spies, Klaus Pietzner, Michael Klum, Clarissa von Haefen, Oliver Hunsicker, Jalid Sehouli, Frank Konietschke and Aarne Feldheiser
    Citation: Intensive Care Medicine Experimental 2023 11:61
  17. Within-breath oscillations in arterial oxygen tension (PaO2) can be detected using fast responding intra-arterial oxygen sensors in animal models. These PaO2 signals, which rise in inspiration and fall in expirat...

    Authors: John N. Cronin, Douglas C. Crockett, Gaetano Perchiazzi, Andrew D. Farmery, Luigi Camporota and Federico Formenti
    Citation: Intensive Care Medicine Experimental 2023 11:60
  18. Immune paralysis can be defined as a hypoinflammatory state associated with the incapacity of the immune system to release proinflammatory mediators despite the clearance of pathogens by antimicrobials. Persis...

    Authors: Mohamed Elayashy, Eman A. Elsayed, Ahmed M. Mukhtar, Sahar Kasem, Sara A. Elmetwally, Sara Habib, Walaa Abdelfattah, Doaa Ghaith and Amr Hussein
    Citation: Intensive Care Medicine Experimental 2023 11:59
  19. High sensitive cardiac troponin T (hsTnT) is a widely used biomarker of myocardial injury. Along with other high sensitive troponins, HsTnT can predict mortality in both cardiac and non-cardiac surgery. The ai...

    Authors: Andreas Koköfer, Crispiana Cozowicz, Bernhard Wernly and Niklas Rodemund
    Citation: Intensive Care Medicine Experimental 2023 11:58
  20. Cerebrovascular reactivity has been identified as a key contributor to secondary injury following traumatic brain injury (TBI). Prevalent intracranial pressure (ICP) based indices of cerebrovascular reactivity...

    Authors: Alwyn Gomez, Amanjyot Singh Sainbhi, Kevin Y. Stein, Nuray Vakitbilir, Logan Froese and Frederick A. Zeiler
    Citation: Intensive Care Medicine Experimental 2023 11:57
  21. Traumatic brain injury (TBI) is a significant cause of death and disability, with no effective neuroprotective drugs currently available for its treatment. Mesenchymal stromal cell (MSC)-based therapy shows pr...

    Authors: Elisa R. Zanier, Francesca Pischiutta, Eliana Rulli, Alessia Vargiolu, Francesca Elli, Paolo Gritti, Giuseppe Gaipa, Daniela Belotti, Gianpaolo Basso, Tommaso Zoerle, Nino Stocchetti and Giuseppe Citerio
    Citation: Intensive Care Medicine Experimental 2023 11:56
  22. Norepinephrine is a commonly used drug for treating vasoplegic acute circulatory failure in ICU. The prediction of norepinephrine macro- and micro-circulatory response is complicated by its uneven receptors’ d...

    Authors: Stefan Andrei, Stéphane Bar, Maxime Nguyen, Bélaid Bouhemad and Pierre-Grégoire Guinot
    Citation: Intensive Care Medicine Experimental 2023 11:52
  23. Circulatory shock is defined syndromically as hypotension associated with tissue hypoperfusion and often subcategorized according to hemodynamic profile (e.g., distributive, cardiogenic, hypovolemic) and etiol...

    Authors: Sabri Soussi, Claudia dos Santos, Jacob C. Jentzer, Alexandre Mebazaa, Etienne Gayat, Janine Pöss, Hannah Schaubroeck, Filio Billia, John C. Marshall and Patrick R. Lawler
    Citation: Intensive Care Medicine Experimental 2023 11:50
  24. The immuno-receptor Triggering Expressed on Myeloid cells-1 (TREM-1) is activated during bacterial infectious diseases, where it amplifies the inflammatory response. Small studies suggest that TREM-1 could be ...

    Authors: Sébastien Gibot, Thomas Lafon, Laurent Jacquin, Benjamin Lefevre, Antoine Kimmoun, Anne Guillaumot, Marie-Reine Losser, Marion Douplat, Laurent Argaud, Guillaume De Ciancio, Lucie Jolly, Nina Touly, Marc Derive, Catherine Malaplate, Amandine Luc, Cédric Baumann…
    Citation: Intensive Care Medicine Experimental 2023 11:51
  25. Steep Trendelenburg position combined with capnoperitoneum can lead to pulmonary complications and prolonged affection of postoperative lung function. Changes in pulmonary function occur independent of differe...

    Authors: Mustafa Syrafe, Wiebke Köhne, Andre Börgers, Heinrich Löwen, Susanne Krege and Harald Groeben
    Citation: Intensive Care Medicine Experimental 2023 11:49
  26. Despite current broad natural and vaccine-induced protection, a substantial number of patients infected with emerging SARS-CoV-2 variants (e.g., BF.7 and BQ.1.1) still experience severe COVID-19. Real-life stu...

    Authors: Nicolas de Prost, Etienne Audureau, Sébastien Préau, Raphaël Favory, Aurélie Guigon, Pierre Bay, Nicholas Heming, Elyanne Gault, Tài Pham, Amal Chaghouri, Guillaume Voiriot, Laurence Morand-Joubert, Sébastien Jochmans, Aurélia Pitsch, Sylvie Meireles, Damien Contou…
    Citation: Intensive Care Medicine Experimental 2023 11:48
  27. The aim of this study is to evaluate the impact of commonly administered sedatives (Propofol, Alfentanil, Fentanyl, and Midazolam) and vasopressor (Dobutamine, Ephedrine, Noradrenaline and Vasopressin) agents ...

    Authors: Logan Froese, Emma Hammarlund, Cecilia A. I. Åkerlund, Jonathan Tjerkaski, Erik Hong, Caroline Lindblad, David W. Nelson, Eric P. Thelin and Frederick A. Zeiler
    Citation: Intensive Care Medicine Experimental 2023 11:54
  28. Transplant candidates on the waiting list are increasingly challenged by the lack of organs. Most of the organs can only be kept viable within very limited timeframes (e.g., mere 4–6 h for heart and lungs expo...

    Authors: Nodir Madrahimov, Vitalii Mutsenko, Ruslan Natanov, Dejan Radaković, André Klapproth, Mohamed Hassan, Mathias Rosenfeldt, Florian Kleefeldt, Ivan Aleksic, Süleyman Ergün, Christoph Otto, Rainer G. Leyh and Constanze Bening
    Citation: Intensive Care Medicine Experimental 2023 11:46
  29. The autonomic nervous system can modulate the innate immune responses to bacterial infections via the splanchnic sympathetic nerves. Here, we aimed to determine the effects of bilateral splanchnic sympathetic ...

    Authors: Rachel M. Peiris, Clive N. May, Lindsea C. Booth, Robin M. McAllen, Michael J. McKinley, Sally Hood, Davide Martelli, Rinaldo Bellomo and Yugeesh R. Lankadeva
    Citation: Intensive Care Medicine Experimental 2023 11:53
  30. Currently, there is a lack of methods for simultaneous assessment of readiness for decannulation of the veno-venous (V-V) and veno-arterial (V-A) components during veno-arteriovenous (V-AV) extracorporal membr...

    Authors: Johannes Heymer, Anna Hein, Matthias Ott, Tobias Schilling and Daniel Räpple
    Citation: Intensive Care Medicine Experimental 2023 11:47
  31. Patients on mechanical ventilation may receive intravenous fluids via restrictive or liberal fluid management. A clear and objective differentiation between restrictive and liberal fluid management strategies ...

    Authors: Eduardo Butturini de Carvalho, Denise Battaglini, Chiara Robba, Manu L. N. G. Malbrain, Paolo Pelosi, Patricia Rieken Macedo Rocco and Pedro Leme Silva
    Citation: Intensive Care Medicine Experimental 2023 11:44
  32. Preclinical sepsis models have been criticized for their inability to recapitulate human sepsis and suffer from methodological shortcomings that limit external validity and reproducibility. The National Precli...

    Authors: Neha Sharma, Damian Chwastek, Dhruva J. Dwivedi, Jared Schlechte, Ian-Ling Yu, Braedon McDonald, Jaskirat Arora, Erblin Cani, Mikaela Eng, Doreen Engelberts, Eva Kuhar, Sarah K. Medeiros, Stephane L. Bourque, Gediminas Cepinskas, Sean E. Gill, Forough Jahandideh…
    Citation: Intensive Care Medicine Experimental 2023 11:45
  33. Definition of temporal serum proteome profiles after out-of-hospital cardiac arrest may identify biological processes associated with severe hypoxia–ischaemia and reperfusion. It may further explore interventi...

    Authors: Gabriele Lileikyte, Anahita Bakochi, Ashfaq Ali, Marion Moseby-Knappe, Tobias Cronberg, Hans Friberg, Gisela Lilja, Helena Levin, Filip Årman, Sven Kjellström, Josef Dankiewicz, Christian Hassager, Johan Malmström and Niklas Nielsen
    Citation: Intensive Care Medicine Experimental 2023 11:43
  34. The driving pressure (ΔP) has an independent association with outcome in patients with acute respiratory distress syndrome (ARDS). INTELLiVENT-Adaptive Support Ventilation (ASV) is a closed-loop mode of ventilati...

    Authors: Laura A. Buiteman-Kruizinga, David M. P. van Meenen, Lieuwe D. J. Bos, Pim L. J. van der Heiden, Frederique Paulus and Marcus J. Schultz
    Citation: Intensive Care Medicine Experimental 2023 11:42
  35. Variation of inferior vena cava (IVC) is used to predict fluid-responsiveness, but the IVC visualization with standard sagittal approach (SC, subcostal) cannot be always achieved. In such cases, coronal trans-...

    Authors: Filippo Sanfilippo, Luigi La Via, Veronica Dezio, Paolo Amelio, Giulio Genoese, Federico Franchi, Antonio Messina, Chiara Robba and Alberto Noto
    Citation: Intensive Care Medicine Experimental 2023 11:40
  36. Diaphragmatic dysfunction is well documented in patients receiving mechanical ventilation. Inspiratory muscle training (IMT) has been used to facilitate weaning by strengthening the inspiratory muscles, yet th...

    Authors: Timothy O. Jenkins, Vicky MacBean, Mathias Krogh Poulsen, Dan Stieper Karbing, Stephen Edward Rees, Brijesh V. Patel and Michael I. Polkey
    Citation: Intensive Care Medicine Experimental 2023 11:41
  37. The level of quadriceps strength (QS) generated in the supine or seated position is not similar. For QS follow-up from intensive care unit (ICU) stay to recovery, getting comparable measures is essential. This...

    Authors: Anne-Françoise Rousseau, Nadia Dardenne, Isabelle Kellens, Stephen Bornheim, Benoit Misset and Jean-Louis Croisier
    Citation: Intensive Care Medicine Experimental 2023 11:39
  38. Endotracheal tube (ETT) clamping before disconnecting the patient from the mechanical ventilator is routinely performed in patients with acute respiratory distress syndrome (ARDS) to minimize alveolar de-recru...

    Authors: Enrico Bulleri, Cristian Fusi, Stefano Bambi, Luigi Pisani, Alice Galesi, Enrico Rizzello, Alberto Lucchini, Paolo Merlani and Alberto Pagnamenta
    Citation: Intensive Care Medicine Experimental 2023 11:36
  39. Inhalation injury can lead to pulmonary complications resulting in the development of respiratory distress and severe hypoxia. Respiratory distress is one of the major causes of death in critically ill patient...

    Authors: Paul A. Mountford, Premila D. Leiphrakpam, Hannah R. Weber, Andrea McCain, Robert M. Scribner, Robert T. Scribner, Ernesto M. Duarte, Jie Chen, Dragana Noe, Mark A. Borden and Keely L. Buesing
    Citation: Intensive Care Medicine Experimental 2023 11:35
  40. Vilobelimab, a complement 5a (C5a)-specific monoclonal antibody, reduced mortality in critically ill COVID-19 patients in a phase 3 multicentre, randomized, double-blind, placebo-controlled study. As part of t...

    Authors: Endry H. T. Lim, Alexander P. J. Vlaar, Sanne de Bruin, Simon Rückinger, Claus Thielert, Maria Habel, Renfeng Guo, Bruce P. Burnett, James Dickinson, Matthijs C. Brouwer, Niels C. Riedemann and Diederik van de Beek
    Citation: Intensive Care Medicine Experimental 2023 11:37
  41. Intravenous oxygen therapeutics present an appealing option for improving arterial oxygenation in patients with acute hypoxemic respiratory failure, while limiting iatrogenic injury from conventional respirato...

    Authors: Jarrod M. Mosier, Saad Sammani, Carrie Kempf, Evan Unger and Joe G. N. Garcia
    Citation: Intensive Care Medicine Experimental 2023 11:33
  42. Optimal anticoagulation strategies for COVID-19 patients with the acute respiratory distress syndrome (ARDS) on venovenous extracorporeal membrane oxygenation (VV ECMO) remain uncertain. A higher incidence of ...

    Authors: Daniel A. Hofmaenner, David Furfaro, Lennart C. Wild, Pedro David Wendel-Garcia, Elias Baedorf Kassis, Ameeka Pannu, Tobias Welte, Rolf Erlebach, Klaus Stahl, Edward Wilson Grandin, Christian Putensen, Reto A. Schuepbach, Shahzad Shaefi, Sascha David, Benjamin Seeliger and Christian Bode
    Citation: Intensive Care Medicine Experimental 2023 11:38
  43. In intensive care, different central venous catheters (CVC) are often used for infusion of drugs. If a patient is treated with continuous renal replacement therapy (CRRT) a second catheter, a central venous di...

    Authors: Anna Bandert, Miklós Lipcsey, Robert Frithiof, Anders Larsson and David Smekal
    Citation: Intensive Care Medicine Experimental 2023 11:32