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Intensive Care Medicine Experimental

Table 4 Blood nitrite + nitrate (NO 2 − + NO 3 − , in nmol·mL −1 ), cytokine, and chemokine concentrations

From: Adrenomedullin binding improves catecholamine responsiveness and kidney function in resuscitated murine septic shock

 

Vehicle

HAM1101

p value

NO2 − + NO3 −

111 (59, 121)

92 (47, 93)

0.170

TNF-α

32 (13, 62)

1 (0, 8)

0.010

IL-6

363 (120, 681)

43 (22, 55)

0.002

IL-10

33 (10, 81)

3 (2, 6)

0.004

KC

2923 (1873, 7138)

650 (516, 1577)

0.016

MCP-1

1130 (779, 1738)

509 (335, 614)

0.005

  1. The data are for vehicle-treated (n = 11) and HAM1101-treated (n = 9) animals. Blood samples were taken at the end of the experiment. TNF-α, tumor necrosis factor-α; IL-6, interleukin-6; IL-10, interleukin-10; KC, keratinocyte-derived chemokine; MCP-1, monocyte chemoattractant protein-1. All parameters are in pg·mL−1. All data are median (quartiles).
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