TY - JOUR AU - Struck, Joachim AU - Hein, Frauke AU - Karasch, Siegmund AU - Bergmann, Andreas PY - 2013 DA - 2013/10/29 TI - Epitope specificity of anti-Adrenomedullin antibodies determines efficacy of mortality reduction in a cecal ligation and puncture mouse model JO - Intensive Care Medicine Experimental SP - 3 VL - 1 IS - 1 AB - Adrenomedullin (ADM), a circulating vasodilatory peptide, plays an important role in the development of sepsis-associated hemodynamic and microcirculatory disorders. While administration of exogenous ADM had beneficial effects in several septic animal models, elevated ADM concentrations are associated with a bad outcome. This prompted us to test the effect of various anti-ADM antibodies in a cecal ligation and puncture (CLP) mouse model. SN - 2197-425X UR - https://doi.org/10.1186/2197-425X-1-3 DO - 10.1186/2197-425X-1-3 ID - Struck2013 ER -