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Intensive Care Medicine Experimental
Figure 2 | Intensive Care Medicine Experimental

Figure 2

From: Epitope specificity of anti-Adrenomedullin antibodies determines efficacy of mortality reduction in a cecal ligation and puncture mouse model

Figure 2

Dose/response curves for various anti-ADM antibodies affecting ADM-induced cAMP response in an ADM bioassay (antagonist activity). The monoclonal antibodies used were directed against the N-terminus (NT-M), mid-region (MR-M) and C-terminus (CT-M) of mouse ADM in the presence of 0.67 nM mouse ADM (panel A), and directed against the N-terminus (NT-H), mid-region (MR-H) and C-terminus (CT-H) of human ADM in the presence of 5.63 nM human ADM (panel B).

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