Acid–base changes after fluid bolus: sodium chloride vs. sodium octanoate

Intensive Care Medicine Experimental

Table 2 Variable differences using RM-ANOVA model fitting main effects for group, time, and group-time interaction

Variable	Question	Test	P value
Hematocrit	Is there an overall difference between saline and octanoate over the 6-h observation period in healthy conscious sheep?	Group effect RM-ANOVA	0.055
Hematocrit	Does octanoate behave differently from saline over time in the 6-h observation period in healthy conscious sheep?	Interaction between group and time RM-ANOVA	0.479
pH	Is there an overall difference between saline and octanoate over the 6-h observation period in healthy conscious sheep?	Group effect RM-ANOVA	<0.001
pH	Does octanoate behave differently from saline over time in the 6-h observation period in healthy conscious sheep?	Interaction between group and time RM-ANOVA	0.011
BE	Is there an overall difference between saline and octanoate over the 6-h observation period in healthy conscious sheep?	Group effect RM-ANOVA	<0.001
BE	Does octanoate behave differently from saline over time in the 6-h observation period in healthy conscious sheep?	Interaction between group and time RM-ANOVA	0.370

BE, base excess; RM-ANOVA, repeated measures analysis of variance. Variables (hematocrit, ph, BE), group (saline and octanoate), and time (0 to 6 h). Because of multiple comparisons, only P < 0.01 was considered statistically significant.