Acid–base changes after fluid bolus: sodium chloride vs. sodium octanoate

Intensive Care Medicine Experimental

Table 3 Differences in electrolyte changes using RM-ANOVA model fitting main effects for group, time, and group-time interaction

Variable	Question	Test	P value
Change in sodium	Is there an overall difference between saline and octanoate over the 6-hobservation period in healthy conscious sheep?	Group effect RM-ANOVA	0.830
Change in sodium	Does octanoate behave differently from saline over time in the 6-hobservation period in healthy conscious sheep?	Interaction between group and time RM-ANOVA	0.800
Change in bicarbonate	Is there an overall difference between saline and octanoate over the 6-h observation period in healthy conscious sheep?	Group effect RM-ANOVA	<0.001
Change in bicarbonate	Does octanoate behave differently from saline over time in the 6-h observation period in healthy conscious sheep?	Interaction between group and time RM-ANOVA	0.004
Change in chloride	Is there an overall difference between saline and octanoate over the 6-h observation period in healthy conscious sheep?	Group effect RM-ANOVA	<0.001
Change in chloride	Does octanoate behave differently from saline over time in the 6-h observation period in healthy conscious sheep?	Interaction between group and time RM-ANOVA	0.147

Variables (change in sodium, bicarbonate, chloride), group (saline and octanoate), and time (0 to 6 h).Because of multiple comparisons, only P < 0.01 was considered statistically significant.