Skip to main content

Table 1 Systemic and renal hemodynamic variables in the renal cortex and medulla at three sampling points

From: Activated protein C ameliorates impaired renal microvascular oxygenation and sodium reabsorption in endotoxemic rats

  BL (t= 0 min) LPS (t= 60 min) FR (t= 180 min)
MAP (mmHg)         
 Time control 99 (97–103) 99 (94–99)   90 (85–94)  
 LPS + FR 102 (96–109) 77 (73–93) T 68 (44–79) T
 APC10 100 (99–102) 76 (69–84) T 72 (59–78) T
 APC100 102 (102–103) 78 (76–92) T 81 (70–89) T
RBF (mL/min)         
 Time control 6.2 (5.8-6.3) 5.9 (4.7-6.1)   5.1 (4.7-5.8)  
 LPS + FR 6.8 (6.0-6.8) 3.1 (3.1-3.3) T 4.6 (2.2-5.1) T
 APC10 6.6 (5.0-7.1) 3.2 (1.7-4.5) T 4.1 (2.8-5.1) T
 APC100 6.0 (5.9-6.8) 3.2 (2.3-4.2) T 4.2 (2.8-4.7) T
RVR (dyn s−1 cm−5)         
 Time control 1,319 (1,251-1,373) 1,347 (1,301-1,579)   1,332 (1,280-1,558)  
 LPS + FR 1,276 (1,183-1,407) 1,901 (1,620-2,673) T 1,311 (828–2,314)  
 APC10 1,267 (1,124-1,635) 2,086 (1,353-3,222) T 1,371 (938–2,038)  
 APC100 1,331 (1,203-1,407) 2,024 (1,761-2,743) T 1,636 (1,383-1,864)  
Hb (g/dL)         
 Time control 0.19 (0.18-0.20) 0.18 (0.17-0.20)   0.18 (0.15-0.19)  
 LPS + FR 0.19 (0.17-0.20) 0.17 (0.17-0.18)   0.13 (0.12-0.14) T
 APC10 0.19 (0.18-0.20) 0.19 (0.17-0.20)   0.13 (0.12-0.14) T
 APC100 0.19 (0.18-0.19) 0.18 (0.17-0.19)   0.13 (0.11-0.14) T
DO2 (mL O2/min/g)         
 Time control 0.90 (0.82-0.95) 0.80 (0.60-0.93)   0.69 (0.56-0.78)  
 LPS + FR 0.87 (0.77-0.96) 0.39 (0.37-0.43) T 0.46 (0.22-0.48) T
 APC10 0.89 (0.81-0.99) 0.41 (0.26-0.63) T 0.40 (0.25-0.52) T
 APC100 0.85 (0.80-0.97) 0.45 (0.28-0.61) T 0.37 (0.29-0.49) T
VO2 (mL O2/min/g)         
 Time control 0.16 (0.12-0.20) 0.18 (0.08-0.26)   0.18 (0.16-0.19)  
 LPS + FR 0.13 (0.12-0.17) 0.11 (0.08-0.15)   0.17 (0.11-0.18)  
 APC10 0.18 (0.12-0.19) 0.13 (0.07-0.16)   0.14 (0.11-0.20)  
 APC100 0.17 (0.13-0.24) 0.12 (0.10-0.17)   0.16 (0.14-0.21)  
CμPO2 (mmHg)         
 Time control 86 (82–87) 85 (78–92)   71 (66–79)  
 LPS + FR 83 (77–87) 69 (65–77) T 49 (43–51) T
 APC10 82 (81–87) 75 (65–83) T 56 (49–59) T
 APC100 80 (75–88) 67 (64–75) T 68 (54–71)  
MμPO2 (mmHg)         
 Time control 65 (59–66) 62 (57–67)   58 (53–60)  
 LPS + FR 55 (51–66) 55 (50–57) T 40 (35–44) T
 APC10 62 (55–64) 53 (47–60) T 45 (39–49) T
 APC100 59 (55–69) 55 (49–59) T 55 (49–58)  
  1. Data are presented as median (25% to 75% percentiles). MAP, mean arterial pressure; RBF, renal blood flow; RVR, renal vascular resistance; Hb, arterial hemoglobin level; DO2, renal oxygen delivery; VO2, renal oxygen consumption; CμPO2, microvascular oxygen tension in the renal cortex; microvascular oxygen tension in the medulla (MμPO2); BL, baseline (BL); LPS, lipopolysaccharide; FR, fluid resuscitation. T p < 0.05 vs time control.