| BL (t= 0 min) | LPS (t= 60 min) | FR (t= 180 min) | |||||
---|---|---|---|---|---|---|---|---|
MAP (mmHg) | Â | Â | Â | Â | Â | Â | Â | Â |
 Time control | 99 | (97–103) | 99 | (94–99) |  | 90 | (85–94) |  |
 LPS + FR | 102 | (96–109) | 77 | (73–93) | T | 68 | (44–79) | T |
 APC10 | 100 | (99–102) | 76 | (69–84) | T | 72 | (59–78) | T |
 APC100 | 102 | (102–103) | 78 | (76–92) | T | 81 | (70–89) | T |
RBF (mL/min) | Â | Â | Â | Â | Â | Â | Â | Â |
 Time control | 6.2 | (5.8-6.3) | 5.9 | (4.7-6.1) |  | 5.1 | (4.7-5.8) |  |
 LPS + FR | 6.8 | (6.0-6.8) | 3.1 | (3.1-3.3) | T | 4.6 | (2.2-5.1) | T |
 APC10 | 6.6 | (5.0-7.1) | 3.2 | (1.7-4.5) | T | 4.1 | (2.8-5.1) | T |
 APC100 | 6.0 | (5.9-6.8) | 3.2 | (2.3-4.2) | T | 4.2 | (2.8-4.7) | T |
RVR (dyn s−1 cm−5) |  |  |  |  |  |  |  |  |
 Time control | 1,319 | (1,251-1,373) | 1,347 | (1,301-1,579) |  | 1,332 | (1,280-1,558) |  |
 LPS + FR | 1,276 | (1,183-1,407) | 1,901 | (1,620-2,673) | T | 1,311 | (828–2,314) |  |
 APC10 | 1,267 | (1,124-1,635) | 2,086 | (1,353-3,222) | T | 1,371 | (938–2,038) |  |
 APC100 | 1,331 | (1,203-1,407) | 2,024 | (1,761-2,743) | T | 1,636 | (1,383-1,864) |  |
Hb (g/dL) | Â | Â | Â | Â | Â | Â | Â | Â |
 Time control | 0.19 | (0.18-0.20) | 0.18 | (0.17-0.20) |  | 0.18 | (0.15-0.19) |  |
 LPS + FR | 0.19 | (0.17-0.20) | 0.17 | (0.17-0.18) |  | 0.13 | (0.12-0.14) | T |
 APC10 | 0.19 | (0.18-0.20) | 0.19 | (0.17-0.20) |  | 0.13 | (0.12-0.14) | T |
 APC100 | 0.19 | (0.18-0.19) | 0.18 | (0.17-0.19) |  | 0.13 | (0.11-0.14) | T |
DO2 (mL O2/min/g) | Â | Â | Â | Â | Â | Â | Â | Â |
 Time control | 0.90 | (0.82-0.95) | 0.80 | (0.60-0.93) |  | 0.69 | (0.56-0.78) |  |
 LPS + FR | 0.87 | (0.77-0.96) | 0.39 | (0.37-0.43) | T | 0.46 | (0.22-0.48) | T |
 APC10 | 0.89 | (0.81-0.99) | 0.41 | (0.26-0.63) | T | 0.40 | (0.25-0.52) | T |
 APC100 | 0.85 | (0.80-0.97) | 0.45 | (0.28-0.61) | T | 0.37 | (0.29-0.49) | T |
VO2 (mL O2/min/g) | Â | Â | Â | Â | Â | Â | Â | Â |
 Time control | 0.16 | (0.12-0.20) | 0.18 | (0.08-0.26) |  | 0.18 | (0.16-0.19) |  |
 LPS + FR | 0.13 | (0.12-0.17) | 0.11 | (0.08-0.15) |  | 0.17 | (0.11-0.18) |  |
 APC10 | 0.18 | (0.12-0.19) | 0.13 | (0.07-0.16) |  | 0.14 | (0.11-0.20) |  |
 APC100 | 0.17 | (0.13-0.24) | 0.12 | (0.10-0.17) |  | 0.16 | (0.14-0.21) |  |
CμPO2 (mmHg) |  |  |  |  |  |  |  |  |
 Time control | 86 | (82–87) | 85 | (78–92) |  | 71 | (66–79) |  |
 LPS + FR | 83 | (77–87) | 69 | (65–77) | T | 49 | (43–51) | T |
 APC10 | 82 | (81–87) | 75 | (65–83) | T | 56 | (49–59) | T |
 APC100 | 80 | (75–88) | 67 | (64–75) | T | 68 | (54–71) |  |
MμPO2 (mmHg) |  |  |  |  |  |  |  |  |
 Time control | 65 | (59–66) | 62 | (57–67) |  | 58 | (53–60) |  |
 LPS + FR | 55 | (51–66) | 55 | (50–57) | T | 40 | (35–44) | T |
 APC10 | 62 | (55–64) | 53 | (47–60) | T | 45 | (39–49) | T |
 APC100 | 59 | (55–69) | 55 | (49–59) | T | 55 | (49–58) |  |