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Intensive Care Medicine Experimental

Table 1 Systemic and renal hemodynamic variables in the renal cortex and medulla at three sampling points

From: Activated protein C ameliorates impaired renal microvascular oxygenation and sodium reabsorption in endotoxemic rats

 

BL (t= 0 min)

LPS (t= 60 min)

FR (t= 180 min)

MAP (mmHg)

        

 Time control

99

(97–103)

99

(94–99)

 

90

(85–94)

 

 LPS + FR

102

(96–109)

77

(73–93)

T

68

(44–79)

T

 APC10

100

(99–102)

76

(69–84)

T

72

(59–78)

T

 APC100

102

(102–103)

78

(76–92)

T

81

(70–89)

T

RBF (mL/min)

        

 Time control

6.2

(5.8-6.3)

5.9

(4.7-6.1)

 

5.1

(4.7-5.8)

 

 LPS + FR

6.8

(6.0-6.8)

3.1

(3.1-3.3)

T

4.6

(2.2-5.1)

T

 APC10

6.6

(5.0-7.1)

3.2

(1.7-4.5)

T

4.1

(2.8-5.1)

T

 APC100

6.0

(5.9-6.8)

3.2

(2.3-4.2)

T

4.2

(2.8-4.7)

T

RVR (dyn s−1 cm−5)

        

 Time control

1,319

(1,251-1,373)

1,347

(1,301-1,579)

 

1,332

(1,280-1,558)

 

 LPS + FR

1,276

(1,183-1,407)

1,901

(1,620-2,673)

T

1,311

(828–2,314)

 

 APC10

1,267

(1,124-1,635)

2,086

(1,353-3,222)

T

1,371

(938–2,038)

 

 APC100

1,331

(1,203-1,407)

2,024

(1,761-2,743)

T

1,636

(1,383-1,864)

 

Hb (g/dL)

        

 Time control

0.19

(0.18-0.20)

0.18

(0.17-0.20)

 

0.18

(0.15-0.19)

 

 LPS + FR

0.19

(0.17-0.20)

0.17

(0.17-0.18)

 

0.13

(0.12-0.14)

T

 APC10

0.19

(0.18-0.20)

0.19

(0.17-0.20)

 

0.13

(0.12-0.14)

T

 APC100

0.19

(0.18-0.19)

0.18

(0.17-0.19)

 

0.13

(0.11-0.14)

T

DO2 (mL O2/min/g)

        

 Time control

0.90

(0.82-0.95)

0.80

(0.60-0.93)

 

0.69

(0.56-0.78)

 

 LPS + FR

0.87

(0.77-0.96)

0.39

(0.37-0.43)

T

0.46

(0.22-0.48)

T

 APC10

0.89

(0.81-0.99)

0.41

(0.26-0.63)

T

0.40

(0.25-0.52)

T

 APC100

0.85

(0.80-0.97)

0.45

(0.28-0.61)

T

0.37

(0.29-0.49)

T

VO2 (mL O2/min/g)

        

 Time control

0.16

(0.12-0.20)

0.18

(0.08-0.26)

 

0.18

(0.16-0.19)

 

 LPS + FR

0.13

(0.12-0.17)

0.11

(0.08-0.15)

 

0.17

(0.11-0.18)

 

 APC10

0.18

(0.12-0.19)

0.13

(0.07-0.16)

 

0.14

(0.11-0.20)

 

 APC100

0.17

(0.13-0.24)

0.12

(0.10-0.17)

 

0.16

(0.14-0.21)

 

CμPO2 (mmHg)

        

 Time control

86

(82–87)

85

(78–92)

 

71

(66–79)

 

 LPS + FR

83

(77–87)

69

(65–77)

T

49

(43–51)

T

 APC10

82

(81–87)

75

(65–83)

T

56

(49–59)

T

 APC100

80

(75–88)

67

(64–75)

T

68

(54–71)

 

MμPO2 (mmHg)

        

 Time control

65

(59–66)

62

(57–67)

 

58

(53–60)

 

 LPS + FR

55

(51–66)

55

(50–57)

T

40

(35–44)

T

 APC10

62

(55–64)

53

(47–60)

T

45

(39–49)

T

 APC100

59

(55–69)

55

(49–59)

T

55

(49–58)

 
  1. Data are presented as median (25% to 75% percentiles). MAP, mean arterial pressure; RBF, renal blood flow; RVR, renal vascular resistance; Hb, arterial hemoglobin level; DO2, renal oxygen delivery; VO2, renal oxygen consumption; CμPO2, microvascular oxygen tension in the renal cortex; microvascular oxygen tension in the medulla (MμPO2); BL, baseline (BL); LPS, lipopolysaccharide; FR, fluid resuscitation. T p < 0.05 vs time control.
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