Skip to main content

Table 3 Blood gas results (mean ± SEM) at 24 h in sham, mildly septic (rats only) and severely septic mice and rats

From: The metabolic phenotype of rodent sepsis: cause for concern?

 

Mouse

Rat

Sham

Severe septic

Sham

Mild septic

Severe septic

pH

7.33 ± 0.03

6.96 ± 0.12*

7.45 ± 0.02

7.44 ± 0.02

7.52 ± 0.04

PCO2 (kPa)

4.29 ± 0.29

8.46 ± 4.14*

4.3 ± 0.1

4.4 ± 0.1

3.2 ± 0.2*

PO2 (kPa)

13.4 ± 4.2

12.2 ± 4.3

13.8 ± 0.2

14.2 ± 0.1

17.6 ± 2.6

HCO3 − (mmol/l)

17.7 ± 0.5

10.9 ± 1.7*

23.9 ± 1.7

23.7 ± 0.8

25.0 ± 1.6

Cl− (mmol/l)

122 ± 5

122 ± 2

106 ± 2

106 ± 2

104 ± 2

BE (mmol/l)

−8.5 ± 0.7

−18.0 ± 3.2*

−1.3 ± 1.9

−1.3 ± 0.9

−3.0 ± 2.6

Lactate (mmol/l)

2.4 ± 0.9

5.0 ± 1.2*

0.8 ± 0.1

1.7 ± 0.3

2.6 ± 0.4*

Glucose (mmol/l)

11.7 ± 4.0

14.9 ± 2.4

7.0 ± 0.7

6.4 ± 0.8

5.4 ± 0.7

Hb (g/dl)

13.2 ± 0.2

15.1 ± 1.6*

12.2 ± 0.5

12.0 ± 1.0

13.9 ± 0.9

MAP at 24 h (mmHg)

-

-

118 ± 2

100 ± 10

95 ± 10

  1. MAP, mean arterial pressure; Hb, haemoglobin concentration; BE, base excess. *p < 0.05 comparing severely septic to sham and mildly septic animals.