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Table 3 Blood gas results (mean ± SEM) at 24 h in sham, mildly septic (rats only) and severely septic mice and rats

From: The metabolic phenotype of rodent sepsis: cause for concern?

  Mouse Rat
Sham Severe septic Sham Mild septic Severe septic
pH 7.33 ± 0.03 6.96 ± 0.12* 7.45 ± 0.02 7.44 ± 0.02 7.52 ± 0.04
PCO2 (kPa) 4.29 ± 0.29 8.46 ± 4.14* 4.3 ± 0.1 4.4 ± 0.1 3.2 ± 0.2*
PO2 (kPa) 13.4 ± 4.2 12.2 ± 4.3 13.8 ± 0.2 14.2 ± 0.1 17.6 ± 2.6
HCO3 (mmol/l) 17.7 ± 0.5 10.9 ± 1.7* 23.9 ± 1.7 23.7 ± 0.8 25.0 ± 1.6
Cl (mmol/l) 122 ± 5 122 ± 2 106 ± 2 106 ± 2 104 ± 2
BE (mmol/l) −8.5 ± 0.7 −18.0 ± 3.2* −1.3 ± 1.9 −1.3 ± 0.9 −3.0 ± 2.6
Lactate (mmol/l) 2.4 ± 0.9 5.0 ± 1.2* 0.8 ± 0.1 1.7 ± 0.3 2.6 ± 0.4*
Glucose (mmol/l) 11.7 ± 4.0 14.9 ± 2.4 7.0 ± 0.7 6.4 ± 0.8 5.4 ± 0.7
Hb (g/dl) 13.2 ± 0.2 15.1 ± 1.6* 12.2 ± 0.5 12.0 ± 1.0 13.9 ± 0.9
MAP at 24 h (mmHg) - - 118 ± 2 100 ± 10 95 ± 10
  1. MAP, mean arterial pressure; Hb, haemoglobin concentration; BE, base excess. *p < 0.05 comparing severely septic to sham and mildly septic animals.