Involvement of caspase-1 in the mechanical ventilation-induced inflammatory response. Pulmonary neutrophil counts expressed as the number of neutrophils per square centimetre tissue and IL-1β and KC levels in lung homogenates expressed as nanogram cytokine per microgram total protein. Data are expressed as box-and-whiskers plots, with min to max range as whiskers. Results of analysis in the non-ventilated (C) and ventilated (V) wild-type (WT) mice, caspase-1 knockout (-/-) mice and pralnacasan-treated mice are shown. *p < 0.05.