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Table 1 Systemic hemodynamics, gas exchange, and metabolism

From: Effects of the PPAR-β/δ agonist GW0742 during resuscitated porcine septic shock

   Before peritonitis 12-h peritonitis 24-h peritonitis
Body temperature (°C) DMSO 36.5 (35.7, 37.4) 37.6 (37.0, 38.4)a 38.4 (37.5, 38.7)a
GW0742 36.9 (36.5, 37.3) 38.1 (37.7, 38.2)a 38.0 (37.7, 38.3)a
Heart rate (min-1) DMSO 83 (70, 99) 144 (121, 149)a 149 (142, 163)a
GW0742 69 (63, 92) 134 (126, 146)a 158 (150, 162)a
Mean arterial pressure (mmHg) DMSO 103 (92, 108) 90 (87, 101)a 75 (65, 98)a
GW0742 110 (106, 114) 97 (93, 100)a 83 (75, 94)a
Mean pulmonary artery pressure (mmHg) DMSO 25 (22, 26) 38 (28, 42)a 39 (35, 40)a
GW0742 27 (24, 27) 35 (34, 38)a 42 (38, 47)a
Central venous pressure (mmHg) DMSO 13 (9, 14) 15 (12, 17)a 18 (17, 18)a
GW0742 13 (11, 15) 15 (13, 17)a 19 (17, 22)a
Pulmonary artery occluded pressure (mmHg) DMSO 13 (10, 14) 15 (14, 17)a 17 (17, 19)a
GW0742 15 (11, 17) 16 (14, 18)a 17 (16, 20)a
Cardiac output (L·min-1) DMSO 4.4 (3.8, 5.2) 6.4 (5.7, 7.9)a 8.0 (5.7, 9.3)a
GW0742 4.4 (3.7, 5.2) 7.1 (6.1, 8.5)a 7.6 (7.1, 7.8)a
Hemoglobin (g·L-1) DMSO 94 (80, 100) 111 (99, 123)a 115 (110, 121)a
GW0742 91 (80, 102) 104 (107, 119)a 110 (107, 119)a
Arterial PO2 (mmHg) DMSO 176 (161, 185) 151 (121, 161) 118 (91, 144)a
GW0742 180 (171, 181) 163 (125, 172) 118 (110, 139)a
PaO2/FiO2 ratio (mmHg) DMSO 550 (502, 583) 459 (362, 503)a 244 (109, 398)a
GW0742 536 (487, 611) 470 (392, 574)a 236 (205, 386)a
Arterial PCO2 (mmHg) DMSO 36 (34, 38) 38 (37, 41) 37 (35, 40)
GW0742 35 (33, 37) 38 (38, 39) 36 (34, 38)
Arterial pH DMSO 7.45 (7.44, 7.46) 7.45 (7.39, 7.46) 7.35 (7.22, 7.41)a
GW0742 7.45 (7.43, 7.46) 7.45 (7.40, 7.47) 7.36 (7.29, 7.41)a
Arterial base excess (mmol·L-1) DMSO 1.2 (-0.3, 1.7) 1.7 (-1.1, 4.3) -4.3 (-11.7, -0.8)a
GW0742 0.4 (-0.5, 0.6) 2.5 (0.5, 4.0) -5.3 (-7.7, -1.6)a
Arterial lactate (mmol·L-1) DMSO 0.8 (0.7, 1.4) 1.0 (0.8, 2.0) 4.1 (1.7, 8.3)a
GW0742 1.1 (0.9, 1.3) 1.0 (.7, 1.4) 2.6 (2.4, 4.5)a
O2 uptake (mL·kg-1·min-1) DMSO 2.5 (2.2, 2.9) 3.0 (2.7, 3.1) 4.1 (3.5, 4.3)a
GW0742 2.6 (2.5, 2.9) 2.7 (2.3, 3.5) 3.8 (3.4, 4.6)a
CO2 production (mL·kg-1·min-1) DMSO 2.4 (2.2, 2.7) 2.8 (2.5, 3.0) 3.2 (3.1, 3.6)a
GW0742 2.3 (2.0, 2.6) 2.6 (2.4, 3.0) 3.2 (2.8, 3.6)a
Blood glucose (mg·dL) DMSO 118 (109, 127) 76 (64, 88)a 94 (73, 120)
GW0742 117 (111, 122) 68 (58, 73)a 75 (69, 83)a
Glucose production (mg·kg-1·min-1] DMSO 1.3 (1.3, 1.5) 2.1 (2.0, 2.5) 3.0 (2.4, 3.3)
GW0742 1.3 (1.2, 1.8) 2.3 (2.1, 2.8) 3.0 (2.8, 3.5)
Glucose oxidation (mg·kg-1·min-1) DMSO 0.4 (0.3, 0.4) 1.3 (1.2, 1.4) 1.7 (1.6, 2.1)
  GW0742 0.3 (0.3, 0.4) 1.4 (1.3, 1.6) 1.9 (1.6, 2.3)
  1. All data are presented as median (quartiles); vehicle (DMSO): n = 12 (n = 11 during 12- to 24-h peritonitis), GW0742: n = 10; a p < 0.05 vs. before peritonitis.