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Table 2 Parameters of renal O 2 exchange, metabolism, function (NGAL - neutrophil gelatinase-associated lipocalin), as well as renal venous biomarkers of inflammation (NO 2 - + NO 3 - - nitrite plus nitrate) and oxidative stress (n.d. - not determined)

From: Effects of the PPAR-β/δ agonist GW0742 during resuscitated porcine septic shock

   Before peritonitis 12-h peritonitis 24-h peritonitis
Renal venous PO2 (mmHg) DMSO 54 (45, 61) 60 (50, 61) 56 (47, 61)
GW0742 53 (47, 55) 58 (52, 63) 56 (48, 60)
Renal venous PCO2 (mmHg) DMSO 40 (38, 41) 44 (41, 45) 45 (41, 47)
GW0742 38 (36, 40) 44 (42, 45) 42 (37, 46)
Renal venous pH DMSO 7.42 (7.41, 7.44) 7.42 (7.36, 7.44) 7.30 (7.12, 7.39)a
GW0742 7.43 (7.40, 7.45) 7.42 (7.38, 7.44) 7.31 (7.23, 7.40)a
Renal venous base excess (mmol1·L-1) DMSO 1.4 (0.0, 2.5) 2.4 (-0.2, 4.7) -4.4 (-12.3, 1.5)a
GW0742 1.0 (0.1, 1.7) 3.3 (1.3, 4.4) -4.7 (-8.2, -2.1)a
Renal venous lactate (mmol1·L-1) DMSO 0.9 (0.7, 1.4) 1.0 (0.9, 1.9) 4.1 (1.3, 9.2)a
GW0742 1.0 (0.7, 1.0) 1.3 (1.2, 1.5) 3.2 (2.1, 4.3)a
Arterial creatinine (μmol1·L-1) DMSO 90 (84, 96) 81 (75, 96) 126 (98, 141)a
GW0742 93 (87, 95) 81 (80, 88) 124 (94, 137)a
Blood NGAL (ng·L-1) DMSO 65 (55, 72) n.d. 364 (270, 400)a
GW0742 56 (53, 61) n.d. 365 (276, 400)a
Urine output (mL·kg-1·h-1) DMSO 8.8 (7.7, 10.4) 3.2 (1.8, 5.1)a
GW0742 10.0 (8.2, 10.7) 3.6 (2.4, 6.7)a
Creatinine clearance (mL1·min-1) DMSO 120 (91, 134) 56 (39, 96)a
GW0742 129 (114, 140) 78 (66, 81)a
Fractional Na+ excretion (%) DMSO 10 (8, 11) 5 (4, 8)a
GW0742 8 (7, 9) 4 (3, 4)a
Renal venous interleukin-6 (ng·L-1) DMSO 96 (77, 139) 1,710 (1,242, 4,807)a 8,405 (2,565, 23,153)a
GW0742 97 (77, 107) 2,656 (1,186, 2,910)a 3,457 (3,348, 3,489)a
Renal venous tumor necrosis factor-α (ng·L-1) DMSO 34 (28, 52) 70 (55, 105)a 125 (91, 172)a
GW0742 49 (42, 126) 63 (50, 84)a 183 (131, 239)a
Renal venous NO2 - + NO3 - (μmol·L-1) DMSO 7 (5, 14) 10 (8, 15) 14 (12, 21)a
GW0742 9 (6, 10) 9 (8, 14) 17 (10, 21)a
Renal venous 8-isoprostane (ng·L-1) DMSO 85 (80, 131) 96 (78, 132) 123 (90, 166)a
  GW0742 83 (72, 109) 91 (70, 113) 123 (87, 264)a
  1. Data on urine output, creatinine clearance, and fractional Na+ excretion refer to 0 to 12 and 12 to 24 h of peritonitis, respectively. All data are presented as median (quartiles); vehicle (DMSO): n = 12 (n = 11 at 24-h peritonitis), GW0742: n = 10; a p < 0.05 vs. before peritonitis.