Effects of the PPAR-β/δ agonist GW0742 during resuscitated porcine septic shock

Wepler, Martin; Hafner, Sebastian; Scheuerle, Angelika; Reize, Matthias; Gröger, Michael; Wagner, Florian; Simon, Florian; Matallo, José; Gottschalch, Frank; Seifritz, Andrea; Stahl, Bettina; Matejovic, Martin; Kapoor, Amar; Möller, Peter; Calzia, Enrico; Georgieff, Michael; Wachter, Ulrich; Vogt, Josef A; Thiemermann, Christoph; Radermacher, Peter; McCook, Oscar

doi:10.1186/2197-425X-1-9

Intensive Care Medicine Experimental

Table 2 Parameters of renal O ₂ exchange, metabolism, function (NGAL - neutrophil gelatinase-associated lipocalin), as well as renal venous biomarkers of inflammation (NO ₂ ^- + NO ₃ ^- - nitrite plus nitrate) and oxidative stress (n.d. - not determined)

From: Effects of the PPAR-β/δ agonist GW0742 during resuscitated porcine septic shock

		Before peritonitis	12-h peritonitis	24-h peritonitis
Renal venous PO₂ (mmHg)	DMSO	54 (45, 61)	60 (50, 61)	56 (47, 61)
Renal venous PO₂ (mmHg)	GW0742	53 (47, 55)	58 (52, 63)	56 (48, 60)
Renal venous PCO₂ (mmHg)	DMSO	40 (38, 41)	44 (41, 45)	45 (41, 47)
Renal venous PCO₂ (mmHg)	GW0742	38 (36, 40)	44 (42, 45)	42 (37, 46)
Renal venous pH	DMSO	7.42 (7.41, 7.44)	7.42 (7.36, 7.44)	7.30 (7.12, 7.39)^a
Renal venous pH	GW0742	7.43 (7.40, 7.45)	7.42 (7.38, 7.44)	7.31 (7.23, 7.40)^a
Renal venous base excess (mmol¹·L^-1)	DMSO	1.4 (0.0, 2.5)	2.4 (-0.2, 4.7)	-4.4 (-12.3, 1.5)^a
Renal venous base excess (mmol¹·L^-1)	GW0742	1.0 (0.1, 1.7)	3.3 (1.3, 4.4)	-4.7 (-8.2, -2.1)^a
Renal venous lactate (mmol¹·L^-1)	DMSO	0.9 (0.7, 1.4)	1.0 (0.9, 1.9)	4.1 (1.3, 9.2)^a
Renal venous lactate (mmol¹·L^-1)	GW0742	1.0 (0.7, 1.0)	1.3 (1.2, 1.5)	3.2 (2.1, 4.3)^a
Arterial creatinine (μmol¹·L^-1)	DMSO	90 (84, 96)	81 (75, 96)	126 (98, 141)^a
Arterial creatinine (μmol¹·L^-1)	GW0742	93 (87, 95)	81 (80, 88)	124 (94, 137)^a
Blood NGAL (ng·L^-1)	DMSO	65 (55, 72)	n.d.	364 (270, 400)^a
Blood NGAL (ng·L^-1)	GW0742	56 (53, 61)	n.d.	365 (276, 400)^a
Urine output (mL·kg^-1·h^-1)	DMSO	8.8	(7.7, 10.4)	3.2 (1.8, 5.1)^a
Urine output (mL·kg^-1·h^-1)	GW0742	10.0	(8.2, 10.7)	3.6 (2.4, 6.7)^a
Creatinine clearance (mL¹·min^-1)	DMSO	120	(91, 134)	56 (39, 96)^a
Creatinine clearance (mL¹·min^-1)	GW0742	129	(114, 140)	78 (66, 81)^a
Fractional Na⁺ excretion (%)	DMSO	10	(8, 11)	5 (4, 8)^a
Fractional Na⁺ excretion (%)	GW0742	8	(7, 9)	4 (3, 4)^a
Renal venous interleukin-6 (ng·L^-1)	DMSO	96 (77, 139)	1,710 (1,242, 4,807)^a	8,405 (2,565, 23,153)^a
Renal venous interleukin-6 (ng·L^-1)	GW0742	97 (77, 107)	2,656 (1,186, 2,910)^a	3,457 (3,348, 3,489)^a
Renal venous tumor necrosis factor-α (ng·L^-1)	DMSO	34 (28, 52)	70 (55, 105)^a	125 (91, 172)^a
Renal venous tumor necrosis factor-α (ng·L^-1)	GW0742	49 (42, 126)	63 (50, 84)^a	183 (131, 239)^a
Renal venous NO₂ ^- + NO₃ ^- (μmol·L^-1)	DMSO	7 (5, 14)	10 (8, 15)	14 (12, 21)^a
Renal venous NO₂ ^- + NO₃ ^- (μmol·L^-1)	GW0742	9 (6, 10)	9 (8, 14)	17 (10, 21)^a
Renal venous 8-isoprostane (ng·L^-1)	DMSO	85 (80, 131)	96 (78, 132)	123 (90, 166)^a
	GW0742	83 (72, 109)	91 (70, 113)	123 (87, 264)^a

Data on urine output, creatinine clearance, and fractional Na⁺ excretion refer to 0 to 12 and 12 to 24 h of peritonitis, respectively. All data are presented as median (quartiles); vehicle (DMSO): n = 12 (n = 11 at 24-h peritonitis), GW0742: n = 10; ^a p < 0.05 vs. before peritonitis.

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