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Table 1 Statistical modeling of the bias between EELV WI-WO and EELV CT as a function of confounding variables

From: Reliability of the nitrogen washin-washout technique to assess end-expiratory lung volume at variable PEEP and tidal volumes

  AIC Statistical significance
Model 1: No explanatory variable 2992  
Model 2: Adjusting for VT 2994 VT: p = 0.55
Model 3: Adjusting for PEEP 2868 PEEP: p < 0.0001
Model 4: Adjusting for EELVBase 2980 EELVBase: p < 0.0001
Model 5: Final model adjusting for VT, PEEP, EELVBase and their three-way interaction 2821 three-way interaction: p < 0.0001
VT × PEEP interaction: p < 0.0001
VT × EELVBase: p < 0.001
PEEP × EELVBase: p < 0.0001
VT: p < 0.001
PEEP: p < 0.0001
   EELVBase: p < 0.05
  1. AIC, Akaike information criterion; EELV, end-expiratory lung volume; EELVBase, EELV baseline value (ARDS onset, PEEP 0 cm H2O); PEEP, positive end-expiratory pressure; VT, tidal volume.