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Table 3 Diagnostic performance of EELV WI-WO to detect variations in ELLV CT at different thresholds

From: Reliability of the nitrogen washin-washout technique to assess end-expiratory lung volume at variable PEEP and tidal volumes

ΔEELVCTthreshold for AUC computation (mL) AUC (CI 95%) Optimal ΔEELVWI-WOcut-off (mL) Se Sp PPV NPV PLR NLR Youden index
100 0.58 (0.50 to 0.66) 42 0.84 0.33 0.57 0.66 1.25 0.48 0.17
150 0.73 (0.64 to 0.81) 166 0.65 0.75 0.46 0.87 2.61 0.47 0.40
200 0.79 (0.70 to 0.89) 166 0.80 0.75 0.42 0.94 3.26 0.27 0.55
250 0.87 (0.79 to 0.94) 169 0.90 0.77 0.41 0.97 3.89 0.13 0.67
300 0.89 (0.83 to 0.95) 169 0.93 0.77 0.41 0.98 4.05 0.09 0.70
  1. AUC, area under receiver operating characteristic curve; CI 95%, 95% confidence interval; ΔEELV CT , absolute change in end-expiratory lung volume assessed by computed tomography between consecutive time points; ΔEELV WI-WO , absolute change in end-expiratory lung volume assessed with the nitrogen washin-washout technique between consecutive time points; NLR, negative likehood ratio; NPV, negative predictive value; PLR, positive likehood ratio; PPV, positive predictive value; Se, sensitivity, Sp, specificity.