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Table 3 Lung function parameters

From: A standardized model of brain death, donor treatment, and lung transplantation for studies on organ preservation and reconditioning

 

Donor

Recipient

Baseline

Before procurement

After reperfusion

P value

PaO2/FiO2, mmHg

540 ± 32

480 ± 31

532 ± 19

0.564

Elastance of respiratory system, cmH2O/L

20.5 ± 7.9

18.4 ± 7.7

22.6 ± 6.9

0.687

Elastance of lung, cmH2O/L

12.9 ± 5.2

15.3 ± 7.7

15.3 ± 7.0

0.846

End expiratory lung volume, mL

735 ± 187

803 ± 312

749 ± 213

0.900

Physiologic dead space fraction

0.54 ± 0.03

0.51 ± 0.07

0.49 ± 0.08

0.631

End-tidal CO2/PaCO2

1.06 ± 0.04

1.13 ± 0.09

1.19 ± 0.08

0.133

Extravascular lung water, mL

359 ± 79

359 ± 80

366 ± 117

0.949

Wet/dry ratio

6.2 ± 7.0

5.8 ± 0.5

5.6 ± 0.6

0.629

  1. Table 3 shows functional lung parameters in the donor and recipient animals. ‘Before procurement’ refers to data taken at the end the donation process at the time of lung procurement, except for wet-to-dry ratio that was measured in sham-operated animals. BD refers to data taken at the end of donor management; ‘After reperfusion’ refers to data taken at the end of post-reperfusion follow-up. Oxygenation of the implanted lung (After reperfusion, n = 3) was assessed by selective left pulmonary vein blood gas analysis. Data are presented as mean ± standard deviation. One-way ANOVA. P < 0.05 accepted as significant.