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Table 3 Hemodynamic and metabolic variables during the ventilatory modes studied

From: Moderately high frequency ventilation with a conventional ventilator allows reduction of tidal volume without increasing mean airway pressure

Variable VT = 6 mL/kg RR = 30 HFPPV = 60 HFPPV = 90 HFPPV = 120 HFPPV = 150 HFOV p valuea
Hemodynamic         
Heart rate (bpm) 144 [125,165] 165 [124,182] 173 [144,181] 169 [130,189] 164 [128,196] 173 [142,196] 145 [122,155] P = 0.210
Cardiac index (mL/kg/min) 138 [128,153] 126 [121,145] 145 [120,169] 127 [115,158] 141 [118,166] 132 [116,168] 126 [101,142] P = 0.363
SV (mL) 28 [26,42] 27 [24,41] 27 [26,35] 26 [23,44] 27 [26,34] 30 [26,35] 31 [22,44] P = 0.916
ABPm (mmHg) 90 [75,107] 86 [75,112] 84 [72,97] 91 [77,100] 83 [70,112] 78 [69,105] 82 [72,98] P = 0.320
PAPm (mmHg) 43 [38,52] 34 [31,37]b 34 [28,36]b 36 [33,37]b 33 [30,47]b 38 [30,43]b 31 [30,40]b P = 0.018
CVP (mmHg) 9 [9,12] 8 [7,12] 8 [6,10] 9 [6,10] 8 [7,10] 9 [7,10] 11 [10,12]c P = 0.017
PAOP (mmHg) 12 [11,15] 12 [11,15] 12 [9,14] 12 [10,14] 12 [10,15] 12 [10,15] 14 [12,17] P = 0.042
SvO2 (mmHg) 54 [47,70] 70 [49,79] 68 [48,71] 63 [48,66] 64 [43,74] 65 [55,73] 65 [50,75] P = 0.140
SVRI (dynes.s-1(cm5)-1.kg-1 51.8 [41.8,56.4] 47.1 [39.8,65.6] 47.0 [35.0,50.9] 52.7 [36.7,61.4] 41.7 [33.4,63.6] 42.4 [28.8,66.5] 50.4 [31.6,55.8] P = 0.558
PVRI (dynes.s-1.(cm5)-1.kg-1 22.3 [17.5,25.7] 15.7 [13.0,16.8] 15.6 [10.9,17.7] 16.7 [13.9,17.7] 14.2 [12.4,20.8] 16.8 [12.0,20.7] 13.6 [10.9,18.2] P = 0.133
Metabolic         
Lactate (mEq/L) 1.7 [1.1,2.1] 1.3 [0.8,1.7] 1.6 [0.8,2.0] 1.7 [1.1,2.0] 1.4 [1.0,1.9] 1.6 [0.9,2.3] 1.5 [1.1,1.8] P = 0.762
pH 7.13 [7.08,7.2] 7.25 [7.24,7.33]b 7.25 [7.24,7.35]b 7.26 [7.23,7.33]b 7.27 [7.2,7.3]b 7.26 [7.21,7.34]b 7.25 [7.2,7.32]b P = 0.002
Temperature (°C) 38.6 [37.3,39.2] 39.7 [38.0,39.8]b 39.4 [37.6,39.6]b 39.2 [38.1,39.6]b 38.8 [37.6,39.6]b 39.0 [37.8,39.5]b 39.2 [38.1,39.8]b P = 0.007
Fluid balance (mL) −50 [−242,−5] 170 [101,278] 40 [−22,102] 100 [67,110] 60 [5,108] 40 [−58,88] 30 [−21,50] P = 0.044
  1. Values are presented as median [P25th,P75th]. aThe p value was obtained through Friedman’s test; bStudent-Newman-Keuls’ post hoc analysis, p < 0.05 vs VT = stabilization step (VT = 6 mL/kg and RR = 35 breaths/min); cStudent-Newman-Keuls’ post hoc analysis, p < 0.05 vs HFPPV = 150.