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Intensive Care Medicine Experimental
Figure 2 | Intensive Care Medicine Experimental

Figure 2

From: Genetic and pharmacologic inhibition of Tpl2 kinase is protective in a mouse model of ventilator-induced lung injury

Figure 2

Lung mechanics. Inspiratory capacity, defined as the volume (in ml/kg) to inflate the lungs to an airway pressure of 25 cmH2O, expressed as percentage (%) of control, of wild-type (WT, white boxes), and Tpl2-deficient mice (Tpl2-/-, gray boxes) subjected only to sample collection (control, n = 8 per group), mechanical ventilation with normal tidal volume (VT) for 240 min (n = 7 to 9 per group), or high VT for 210 min (n = 8 to 9 per group), and WT mice subjected to 210 min of high VT ventilation treated with a Tpl2 inhibitor, either prior (Tpl2inh pre, n = 5) or after initiation of high VT ventilation (Tpl2inh post, n = 5). Wild-type mice subjected to high VT ventilation had lower inspiratory capacity compared to control WT mice, as well as compared to similarly ventilated Tpl2-/-mice, and WT mice treated with the Tpl2 inhibitor, *p < 0.01. Data are presented in box plots, where boxes represent 25th to 75th percentile; line represent median and whisker represent min and max, in all figures.

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