Genetic and pharmacologic inhibition of Tpl2 kinase is protective in a mouse model of ventilator-induced lung injury

Intensive Care Medicine Experimental

Table 1 Experimental groups

Strain treatment	Sample *(N)*
Strain treatment	WT	Tpl2^-/-
Control-PV curve and sample collection	10	10
Normal VT ventilation	8	8
High VT ventilation	8	8
High VT ventilation + Tpl2 inhibitor pretreatment	5
High VT ventilation + Tpl2 inhibitor posttreatment	5
Control-no ventilation (ERK1/2 phosphorylation)	6	6
Normal VT 60 min (ERK1/2 phosphorylation)	4	4
Normal VT 30 min + High VT 30 min (ERK1/2 phosphorylation)	8	8
Normal VT 30 min + High VT 30 min (ERK1/2 phosphorylation) + Tpl2 inhibitor pretreatment	4