Skip to main content

Advertisement

Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Table 2 Parameters of glucose metabolism and mitochondrial respiratory activity

From: Effects of glycemic control on glucose utilization and mitochondrial respiration during resuscitated murine septic shock

  Hyperglycemia Normoglycemia
Vehicle EMD008 Vehicle EMD008
Arterial glucose (mg · dL-1) 151 (146;202)# 138 (128;142)#§ 104 (94;120) 99 (71;122)
Arterial lactate (mmol · L-1) 3.2 (2.6;3.5)# 3.8 (3.0;4.8)# 2.1 (1.9;2.5) 1.8 (1.5;1.9)
CO2 production (μL · min-1) 27 (25;32) 29 (27;31) 27 (25;27) 24 (22;27)
Gluconeogenesis (mg · g-1 · h-1) 0.31 (0.26;0.35)# 0.38 (0.33;0.40)#§ 0.40 (0.38;0.45) 0.53 (0.49;0.53)**
Glucose oxidation (% isotope infusion) 63 (57;67) 62 (59;64) 62 (60;64) 63 (59;66)
JO2-OXPHOS (pmol · s-1) 116 (97;122)# 136 (134;160)#§ 150 (136;177) 185 (167–197)§
JO2-ETC (pmol · s-1) 147 (130;159)# 166 (154;194)#* 183 (171;193) 210 (203;238)§
  1. JO2-OXPHOS and JO2-ETC are maximal oxidative phosphorylation at optimal substrate availability and maximal electron transfer capacity in the uncoupled state, respectively, as O2 consumption rate per 106 cells. All data are median (quartiles). #p < 0.05 vs. normoglycemia; §p < 0.05 vs. vehicle; *p = 0.064 vs. vehicle; **p = 0.073 vs. vehicle.