Skip to main content

Table 3 Signal transduction and mediator proteins

From: Effects of glycemic control on glucose utilization and mitochondrial respiration during resuscitated murine septic shock

 

Hyperglycemia

Normoglycemia

Vehicle

EMD008

Vehicle

EMD008

Tail moment

0.5 (0.5;0.6)

0.6 (0.5;0.7)

0.5 (0.4;0.6)

0.6 (0.4;0.7)

HO-1

1.6 (1.6;1.7)

2.2 (2.0;2.3)§

1.7 (1.6;1.8)

1.9 (1.6;2.2)

Bax

1.7 (1.5;1.9)#

1.3 (1.3;1.3)§

1.3 (1.1;1.3)

1.3 (1.3;1.4)

Caspase-3

1.1 (1.1;1.2)

1.0 (0.9;1.1)

1.1 (1.0;1.3)

0.7 (0.7;0.8)§

AMPK activation

0.6 (0.6-0.7)#

0.8 (0.8;0.9)§

0.8 (0.8;0.9)

0.8 (0.7;0.8)

Total AMPK

1.0 (0.99;1.05)

1.03 (0.98;1.08)

1.0 (0.98;1.02)

1.06 (0.99-1.08)

  1. AMPK activation is expressed as TH172-phosphorylated AMPK in percentage of total AMPK. All values are expressed as fold over control values from animals that had not undergone surgery. All data are median (quartiles). #p < 0.05 vs. normoglycemia; §p < 0.05 vs. vehicle.