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Intensive Care Medicine Experimental
Figure 3 | Intensive Care Medicine Experimental

Figure 3

From: Administration of intrapulmonary sodium polyacrylate to induce lung injury for the development of a porcine model of early acute respiratory distress syndrome

Figure 3

Histology of lung tissue from CON and SPA-treated animals. Histology of lung tissue from control (CON) (A, B) and sodium polyacrylate (SPA)-treated (C, D) animals 6 h after administration of SPA or sham. (A) Bronchiole from CON animal demonstrating normal epithelial structure (hematoxylin-eosin stain, original magnification × 20). (B) Normal alveolar structure in CON animal (hematoxylin-eosin, original magnification × 40). (C) Bronchiole from SPA-treated animal filled with degenerated and viable neutrophils, with transmigration of neutrophils across the respiratory epithelium. Cilia are intact and mild epithelial hyperplasia is present. The subjacent alveoli contain inflammatory cells and fibrin (hematoxylin-eosin stain, original magnification × 20). (D) Macrophages, neutrophils, and fibrin strands in an area of alveolar inflammation and consolidation in tissue from an SPA-treated animal (hematoxylin-eosin stain, original magnification × 40).

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