Administration of intrapulmonary sodium polyacrylate to induce lung injury for the development of a porcine model of early acute respiratory distress syndrome

Intensive Care Medicine Experimental

Table 1 Pulmonary mechanics of animals before and after real injury with SPA or sham injury (CON)

	SPA group before injury	CON group before injury	p value SPA versus CON before injury	SPA group after injury	CON group after injury	p value SPA versus CON after injury	p value SPA before versus after injury	p value CON before versus after injury
E_RS (cm H₂O/L)	33.56 ± 10.03	31.88 ± 2.53	0.77	65.08 ± 29.78	32.88 ± 13.72	0.04	<0.01	0.99
E_L (cm H₂O/L)	21.06 ± 8.34	19.13 ± 2.15	0.76	56.87 ± 25.07	23.68 ± 13.82	0.11	<0.01	0.70
E_CW (cm H₂O/L)	15.98 ± 8.32	13.15 ± 5.51	0.66	18.24 ± 19.01	11.52 ± 4.72	0.64	0.73	0.79
R_RS (cm H₂O/L/s)	10.66 ± 6.83	15.26 ± 6.43	0.31	21.55 ± 10.99	12.99 ± 2.15	0.22	0.01	0.60
R_L (cm H₂O/L/s)	9.59 ± 6.55	16.17 ± 8.05	0.22	21.00 ± 9.61	13.18 ± 2.07	0.29	<0.01	0.67
R_CW (cm H₂O/L/s)	1.58 ± 1.15	1.21 ± 0.66	0.68	2.48 ± 3.55	0.93 ± 0.75	0.57	0.43	0.73

E_RS, elastance of the respiratory system; E_L, elastance of the lung; E_CW, elastance of the chest wall; R_RS, resistance of the respiratory system; R_L, resistance of the lung; R_CW, resistance of the chest wall. All values are reported as mean ± standard deviation.