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Table 3 Principal features of lymphocyte apoptosis studies

From: Uncontrolled sepsis: a systematic review of translational immunology studies in intensive care medicine

Author Study population Subjects ( n) Control population Controls ( n) Experimental context Outcome measure correlated with immune readout
Roger [43] Sepsis 48 Healthy volunteer 15 Pathophysiological No
Bandyopadhyay [58] Trauma 113 Healthy volunteer ? Pathophysiological No
White [11] Sepsis 60 Gram negative infection and healthy volunteer 15 and 20 Pathophysiological Yes
White [11] Elective surgery (infective complications) 19 Cohort 41
Zhang [44] Sepsis 19 Healthy volunteer 22 Pathophysiological No
Guignant [45] Sepsis 64 Healthy volunteer 49 Pathophysiological No
Vaki [46] Sepsis 48 (68) Healthy volunteer 20 Pathophysiological No
Slotwinski [62] Elective surgery 50 (26, 24) Cohort 50 Experimental/clinical outcome No
Gogos [47] Sepsis PN 183, CAP 97, IA 100, PB 61, HAP 64 N/A   Pathophysiological Yes
Hoogerwerf [48] Sepsis 16 Healthy volunteer 24 Pathophysiological No
Yousef [49] Sepsis 32 SIRS and without SIRS 35/33 Patient outcome Yes
Turrel-Davin [50] Sepsis 13 Healthy volunteer 15 Biomarker comparison No
Pelekanou [51] Sepsis VAP 36 Other infections 32 Pathophysiology No
Papadima [61] Elective surgery 40 (21, 19) Cohort 40 Pathophysiological No
Delogu [52] Sepsis 16 ?‘individuals’   Pathophysiological No
Weber [53] Sepsis 16 Non-infected ICU and healthy volunteer 10 and 11 Pathophysiological No
Roth [54] Sepsis 15 Healthy volunteer 20 Pathophysiological No
Le Tulzo [55] Sepsis 47 (25, 23) SIRS and healthy volunteer 7 and 25 Pathophysiological/clinical outcome Yes
Hotchkiss [56] Sepsis 27 (FC 5) (3 intraop, 24 autopsy) Critically ill non-septic and trauma 16 and 25 (FC 6) (3 prospective, 13 retrospective) Pathophysiological No
Delogu [63] Elective surgery 18 Cohort 18 Pathophysiological No
Pellegrini [59] Trauma 17 (+13 burns) Healthy volunteer 17 Clinical outcome/pathophysiological (Correlate to MODS)
Delogu [64] Surgical 15 Healthy volunteer 10 Pathophysiological/patient outcome Yes
Hotchkiss [60] Trauma 10 Elective surgery 6 (all prospective) Pathophysiological No
Hotchkiss [57] Sepsis 20 Non septic prospective/non-septic retrospective/prospective trauma splenectomy/ prospective colectomy/retrospective colectomy 1/9/6/2/8 Pathophysiological No
Sasajima [65] Elective surgery 16 (11, 5) Cohort 16 Pathophysiological No
Sugimoto [66] Elective surgery 10 (5, 5) Cohort 10 Pathophysiological No