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Table 3 Principal features of lymphocyte apoptosis studies
| Author | Study population | Subjects ( n) | Control population | Controls ( n) | Experimental context | Outcome measure correlated with immune readout |
|---|---|---|---|---|---|---|
| Roger [43] | Sepsis | 48 | Healthy volunteer | 15 | Pathophysiological | No |
| Bandyopadhyay [58] | Trauma | 113 | Healthy volunteer | ? | Pathophysiological | No |
| White [11] | Sepsis | 60 | Gram negative infection and healthy volunteer | 15 and 20 | Pathophysiological | Yes |
| White [11] | Elective surgery (infective complications) | 19 | Cohort | 41 | “ | “ |
| Zhang [44] | Sepsis | 19 | Healthy volunteer | 22 | Pathophysiological | No |
| Guignant [45] | Sepsis | 64 | Healthy volunteer | 49 | Pathophysiological | No |
| Vaki [46] | Sepsis | 48 (68) | Healthy volunteer | 20 | Pathophysiological | No |
| Slotwinski [62] | Elective surgery | 50 (26, 24) | Cohort | 50 | Experimental/clinical outcome | No |
| Gogos [47] | Sepsis | PN 183, CAP 97, IA 100, PB 61, HAP 64 | N/A | Pathophysiological | Yes | |
| Hoogerwerf [48] | Sepsis | 16 | Healthy volunteer | 24 | Pathophysiological | No |
| Yousef [49] | Sepsis | 32 | SIRS and without SIRS | 35/33 | Patient outcome | Yes |
| Turrel-Davin [50] | Sepsis | 13 | Healthy volunteer | 15 | Biomarker comparison | No |
| Pelekanou [51] | Sepsis | VAP 36 | Other infections | 32 | Pathophysiology | No |
| Papadima [61] | Elective surgery | 40 (21, 19) | Cohort | 40 | Pathophysiological | No |
| Delogu [52] | Sepsis | 16 | ?‘individuals’ | Pathophysiological | No | |
| Weber [53] | Sepsis | 16 | Non-infected ICU and healthy volunteer | 10 and 11 | Pathophysiological | No |
| Roth [54] | Sepsis | 15 | Healthy volunteer | 20 | Pathophysiological | No |
| Le Tulzo [55] | Sepsis | 47 (25, 23) | SIRS and healthy volunteer | 7 and 25 | Pathophysiological/clinical outcome | Yes |
| Hotchkiss [56] | Sepsis | 27 (FC 5) (3 intraop, 24 autopsy) | Critically ill non-septic and trauma | 16 and 25 (FC 6) (3 prospective, 13 retrospective) | Pathophysiological | No |
| Delogu [63] | Elective surgery | 18 | Cohort | 18 | Pathophysiological | No |
| Pellegrini [59] | Trauma | 17 (+13 burns) | Healthy volunteer | 17 | Clinical outcome/pathophysiological | (Correlate to MODS) |
| Delogu [64] | Surgical | 15 | Healthy volunteer | 10 | Pathophysiological/patient outcome | Yes |
| Hotchkiss [60] | Trauma | 10 | Elective surgery | 6 (all prospective) | Pathophysiological | No |
| Hotchkiss [57] | Sepsis | 20 | Non septic prospective/non-septic retrospective/prospective trauma splenectomy/ prospective colectomy/retrospective colectomy | 1/9/6/2/8 | Pathophysiological | No |
| Sasajima [65] | Elective surgery | 16 (11, 5) | Cohort | 16 | Pathophysiological | No |
| Sugimoto [66] | Elective surgery | 10 (5, 5) | Cohort | 10 | Pathophysiological | No |
