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Table 5 Demographic information of monocyte tolerance studies

From: Uncontrolled sepsis: a systematic review of translational immunology studies in intensive care medicine

Author Age Gender (%male) Subject ethnicity Severity of subject disease Subject drug exposure documentation
Subjects Controls Statistical test result Subjects Controls Statistical test result Index Score No. of groups Sedatives Antibiotics Steroids
Liu [30] ? ? N ? ? N N ? ? 1 N N N
Buttenschoen [41] 56 (33 to 88) N/A N 70 N/A N N ? ? n/a N N N
Pachot [31] 68 (54 to 76) 51 (42 to 65) N 62 52 N N SAPS II 51 (±5) 2 N N N
West [32] N/S N/S N 42 100; 20; 56 N N ? ? 2 N N N
Harter [33] 48 ± 20 'Comparable’ N 71 12 N N APACHE II 13 ± 6 1 N” N N
Flohe [40] 47 ± 18 37 ± 14 N 68 50 N N ISS 39 ± 9 1 N N N
Escoll [34] 51 ± 12 49 ± 12 N ? ? N N ? ? 1 N N N
Heagy [39] 49 ± 3; 44 ± 8 ? N ? ? N N Mortality 20%, 9.6% 2 N N N
Calvano [35] 60; 61 58 N 66; 66 66 N N ? ? 2 N N Yt
Sfeir [36] 63 ± 3 50 ± 7 N* (p < 0.0001) 80 50 N N APACHE II 27 ± 5 1 N N N
Kawasaki [42] ? N/A N ? N/A N N ASA I to II 1 N N N
Heagy [37] 49 ± 21 ? N 66 ? N N ? ? 4 N N N
Bergmann [38] 60; 51 32 N ? ? N N MODS 15 ± 1, 7 ± 1 2 N N N
  1. Age: N/S, not summarised (tabulated data for every patient provided); question mark (?), not provided within the manuscript; N/A, not applicable. Statistical test result: N, not reported; N*, not reported but we identified the significant p value from the original manuscript data. Severity of subject disease: The average clinical severity score of subjects with an index of spread listed in brackets. The number of severity groups which subjects were divided into is listed. ISS/AIS, Injury Severity Score/Abbreviated Injury Severity Score [87]; ASA, American Society of Anesthesiologists Physical Status Classification System [85]; APACHE II: Acute Physiology and Chronic Health Evaluation II [83], APACHE III, Acute Physiology and Chronic Health Evaluation III [84]. Subject drug use detailed: whether patient exposure to known immunomodulating drugs was documented. A‘t’ signifies that the timing of the drug administration in relation to blood sampling was clear from the study methodology.