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Table 1 Gas exchange in an animal model of LPS–induced lung; ventilated with heliox or oxygen-in-air

From: Mechanical ventilation with heliox in an animal model of acute respiratory distress syndrome

  Time (h) Healthy   LPS  
Oxygen-in-air Heliox Oxygen-in-air Heliox
pH 0 7.44 ± 0.04 7.42 ± 0.03 7.35 ± 0.05a 7.34 ± 0.08b
4 7.33 ± 0.04c 7.36 ± 0.03d 7.30 ± 0.06 7.30 ± 0.08
pCO2 (kPa) 0 4.38 ± 0.7 4.86 ± 0.6 5.78 ± 0.6a 6.10 ± 1.4b
4 4.99 ± 0.4 5.81 ± 0.9 5.84 ± 0.77 5.75 ± 1.29
pO2 (kPa) 0 34.2 ± 1.8 31.7 ± 1.5 33.2 ± 1.7 32.3 ± 3.3
4 31.7 ± 2.5 30.8 ± 2.8 28.5 ± 3.9 28.8 ± 3.4
  1. aOxygen-in-air LPS T = 0 vs. oxygen-in-air healthy T = 0, significant after Bonferroni's multiple comparison test (P < 0.01); bHeliox LPS T = 0 vs. heliox healthy T = 0, significant after Bonferroni's multiple comparison test (P < 0.01); cOxygen-in-air healthy T = 0 vs. oxygen-in-air healthy T = 4, significant after Bonferroni correction (P < 0.0125); dHeliox healthy T = 0 vs. heliox healthy T = 4, significant after Bonferroni correction (P < 0.0125). Data are presented as mean ± SD. N = 8 per group.