From: 0727. Normal saline versus ringer´s lactate in experimental sepsis
T0 | T4 | T8 | T12 | T16 | T20 | T24 | T28 | ||
---|---|---|---|---|---|---|---|---|---|
Mean Arterial Pressure (mmHg) | RL | 103 (97-111) | 90 (77-94) | 82 (77-90) | 68 (60-85) | 59 (55-79) | 55 (54-57) | 51 (39-57) | 36 (26-46) |
NS | 97 (93-109) | 88 (79-93) | 67 (63-81)* | 52 (41-63)* | 37 (33-42)* | 46 (36-57)* | 40 (40-40)* | - | |
Cardiac Index (L/min/m²) | RL | 5.1 (4.0-5.6) | 4.4 (3.9-6.6) | 4.7 (3.9-5.1) | 4.6 (3.4-6.0) | 4.3 (3.5-5.4) | 4.9 (3.5-5.9) | 4.6 (2.7-5.0) | 3.9 (3.0-4.7) |
NS | 4.9 (4.0-5.5) | 4.8 (3.8-5.5) | 3.2 (2.6-4.2)* | 2.9 (2.7-3.3)* | 2.1 (1.5-2.8)* | 3.1 (2.9-3.3)* | 1.4 (1.4-1.4)* | - | |
Diuresis (ml/Kg/H) | RL | 1.0 (0.5-2.0) | 0.9 (0.6-2.2) | 1.3 (0.5-2.3) | 1.2 (0.3-2.9) | 0.2 (0.0-1.3) | 0.1 (0.0-0.4) | 0.0 (0.0-0.0) | 0.5 (0.0-1.0) |
NS | 1.0 (0.6-1.8) | 0.9 (0.7-1.2) | 1.3 (0.2-2.8) | 0.2 (0.0-0.4)* | 0.0 (0.0-0.1) | 0.2 (0.0-0.4) | 0.0 (0.0-0.0) | - | |
PaO2/FiO2 ratio | RL | 462 (420-493) | 482 (364-496) | 458 (317-483) | 352 (222-444) | 266 (220-359) | 251 (170-324) | 281 (150-298) | 138 (64-212) |
NS | 388 (322-420) | 385 (284-486) | 268 (259-400)* | 192 (173-299) | 176 (160-292) | 217 (177-257) | 204 (204-204) | - |