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Table 1 Effect of aspirin on markes of pulmonary inflammation

From: 0995. Aspirin reduces neutrophilic pulmonary inflammation in a human model of acute respiratory distress syndrome induced by inhaled lipopolysaccharide

BAL

    
 

Placebo (n=13)

Aspirin (n=20)

% reduction

p-value

PMN (105cells/ml)

2.25 (1.18, 4.67)

1.48 (0.32, 6.21)

34.2

0.03

TNF-α (pg/ml)

105.7 (73.49, 358.5)

79.72 (37.34, 276.6)

24.5

0.02

IL-6 (pg/ml)

856.5 (535.9, 2285)

647.9 (224.6, 1582)

24.1

0.07

MMP-8 (pg/ml)

6342 (1932, 9574)

2902 (862.8, 6758)

54

0.03

MMP-9 (pg/ml)

48493 (23126, 99780)

33717 (10471, 72334)

30.4

0.03

IL-8 (pg/ml)

447.5 (236.9, 1250)

345.9 (175.5, 1522)

22.7

0.11

IL-1β (pg/ml)

42.74 (25.98, 98.76)

37.03 (18.73, 54.88)

13

0.16