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Table 2 Patient characteristics with therapeutic strategy.

From: De-escalation of empiric antibiotic therapy in sepsis - an indian observational study

Variable

No change n

De-escalation n

Escalation n

P value

Number of initial empirical antibiotics 1

58

26

32

0.007

Number of initial empirical antibiotics 2

72

26

36

 

Number of initial empirical antibiotics 3

18

22

8

 

Most Common initial empirical antibiotic

beta lactam +beta lactamase inhibitor

Carbapenem

beta lactam +beta lactamase inhibitor

0.0001

Most Common Escalated /De-escalated Antibiotic

beta lactam +beta lactamase inhibitor

beta lactam +beta lactamase inhibitor

Carbapenem followed by colistin

0.0001

Multi drug resistant organisms

6

8

34

0.0001

ESBL organisms

4

4

10

0.0001

Most Common Source of infection

Lung

Lung

Lung

 

H1N1 POSITIVE patients

29

10

6

0.062