From: De-escalation of empiric antibiotic therapy in sepsis - an indian observational study
Variable | No change n | De-escalation n | Escalation n | P value |
---|---|---|---|---|
Number of initial empirical antibiotics 1 | 58 | 26 | 32 | 0.007 |
Number of initial empirical antibiotics 2 | 72 | 26 | 36 | Â |
Number of initial empirical antibiotics 3 | 18 | 22 | 8 | Â |
Most Common initial empirical antibiotic | beta lactam +beta lactamase inhibitor | Carbapenem | beta lactam +beta lactamase inhibitor | 0.0001 |
Most Common Escalated /De-escalated Antibiotic | beta lactam +beta lactamase inhibitor | beta lactam +beta lactamase inhibitor | Carbapenem followed by colistin | 0.0001 |
Multi drug resistant organisms | 6 | 8 | 34 | 0.0001 |
ESBL organisms | 4 | 4 | 10 | 0.0001 |
Most Common Source of infection | Lung | Lung | Lung | Â |
H1N1 POSITIVE patients | 29 | 10 | 6 | 0.062 |