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Table 1 Clinical data throughout study time.

From: Development and characterization of a novel model of invasive pneumococcal pneumonia in invasively ventilated PIGS

 

Before Bacterial Challenge

24 hours

48 hours

72 hours

P-value

Body Temperature (°C)

36.8 ± 0.9

38.7 ± 0.6

38.6 ± 0.8

38.6 ± 0.5

< 0.001

(°C) White Blood Cell (cells/µL)

11,833 ± 4,706

8,237 ± 2,443

19,070 ± 9,229

14,817 ± 7,579

0.042

Platelets (cells/µL)

423,125 ± 104,120

228,625 ± 60,133

164,712 ± 65,953

209,000 ± 71,288

< 0.001

PaO2/FiO2

441.7 ± 62.7

321.1 ± 35.7

288.3 ± 89.9

375.6 ± 52.6

< 0.001

PaCO2 (mmHg)

47.2 ± 6.3

56.0 ± 8.6

41.0 ± 6.0

37.0 ± 5.7

< 0.001

Lung Elastance (cmH2O/L)

14.2 ± 3.2

28.6 ± 16.1

26.5 ± 15.7

26.6 ± 0.5

0.301

Pulmonary Shunt (%)

4.2 ± 2.0

14.8 ± 4.9

13.5 ± 2.9

8.9 ± 3.2

< 0.001

Mean Arterial Pressure (mmHg)

81.2 ± 10.4

68.3 ± 5.4

68.4 ± 3.9

72.9 ± 8.4

0.074

Systemic Vascular Resistance (dynes*sec/cm5)

1857 ± 643

1048 ± 355

1142 ± 377

1419 ± 516

0.014