Table 1 Results.
From: Respiratory and hemodynamic effects of intravenous nalbuphin in anesthetized rats
Placebo (n=6) | Nalbuphin 1 mg/kg/h (n=6) | p-value | Placebo (n=6) | Nalbuphin 5 mg/kg iv (n=6) | p-value | |
|---|---|---|---|---|---|---|
Nalbuphin concentration [mg/l] | 22.9 (3.7) | |||||
Respiratory parameters | ||||||
Respiration rate [1/min] | 55 (3) | 45 (2) | 0.02 | 53 (4) | 41 (2) | 0.04 |
pO2 [kPa] | 9.31 (0.41) | 7.86 (0.98) | 0.41 | 10.1 (0.66) | 6.81 (0.36) | 0.02 |
SaO2 [%] | 92.7 (1.2) | 83.9 (3.3) | 0.09 | 93.6 (1.3) | 78 (2.7) | 0.02 |
pCO2 [kPa] | 6.25 (0.31) | 7.72 (0.52) | 0.03 | 6.45 (0.53) | 8.49 (0.39) | 0.01 |
Hemodynamic parameters | ||||||
Heart rate (1/min) | 409 (10) | 336 (12) | 0.00 | 413 (14) | 332 (16) | 0.01 |
Mean arterial pressure (mmHg) | 95 (6) | 78 (4) | 0.04 | 92 (5) | 70 (3) | 0.01 |