- Poster presentation
- Open access
- Published:
Middle molecules in severe community-acquired pneumonia
Intensive Care Medicine Experimental volume 3, Article number: A791 (2015)
Introduction
In recent years there is a revival of interest to the plasma level of middle molecules which is the marker of activation of endogenous proteolysis and the expressiveness of endogenous intoxication syndrome.
Objectives
To examine the state of middle molecules (MM) in the blood plasma of patients with severe community-acquired pneumonia (CAP).
Methods
Retrospective analysis of 23 cases of severe CAP hospitalized in Critical Care Unit of Sfanta Treime Municipal Hospital, Chisinau, from October 2014 to February 2015. The measurements of level of the peptide substances belonging to a group of “middle molecules” (MM) using spectrophotometer were carried out and the results were compared to the levels of 11 healthy controls.
Results
Patients admitted had mean age of 62 ± 1.2 years, PORT classes IV-V and mean Pneumonia Severity Index score of 108.5 ± 3.8. In all patients on admission there was a high level of endogenous intoxication manifested by 1.8 times increasing levels of MM compared to the control group (0.262 ± 0.001 versus 0.146 ± 0.02 optic units, p < 0.05). There was a positive trend with a decline of MM on day 7 - 0.248 ± 0.001. No positive correlation was found between MM and other laboratory parameters with the exception of increased band neutrophils (r = 0.71, p < 0.05). ICU-mortality constituted 21.7% (5/23). In patients who died MM level was 0.438 ± 0.002 optic units, which was 3 times higher compared to the control group (p < 0.05).
Conclusions
Determining the plasma level of middle molecules can be used as an additional dynamic criterion of severity of endogenous intoxication in community-acquired pneumonia.
References
Makarevich A, et al: The effect of extracorporeal efferent detoxication methods inclusion in the severe community-acquired pneumonia treatment. Advances in Medical Science. 2006, 51: 73-87.
Nikolajchik VV, et al: The method of detection of “middle molecules”. Labor Work. 1991, 10: 13-8.
Author information
Authors and Affiliations
Rights and permissions
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made.
The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.
To view a copy of this licence, visit https://creativecommons.org/licenses/by/4.0/.
About this article
Cite this article
Dumitras, T., Garbuz, V., Gutu-Bahov, C. et al. Middle molecules in severe community-acquired pneumonia. ICMx 3 (Suppl 1), A791 (2015). https://doi.org/10.1186/2197-425X-3-S1-A791
Published:
DOI: https://doi.org/10.1186/2197-425X-3-S1-A791