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Table 1 Distribution of biomarkers within 24 hours.

From: Biomarkers mesuared within 24 hours from the onset of septic shock and 28-day mortality

Biomarker

Overall population N = 100 Median (IQR)

Survivors (n = 64) Median (IQR)

Non-Survivors (n = 36) Median (IQR)

P*

Age

64 (54.25-71)

63 (49-69)

66.5 (59-72.75)

0.04

APACHE II

26 (21.5-29.5)

25 (19-29)

27 (22.75-33)

0.002

SOFA

10 (8-12)

10 (8-11)

12 (10-14)

< 0.001

MR-proADM (nmol/L)

1.71 (0.65-4.11)

1.06 (0.53-3.03)

2.84 (1.1-4.75)

0.002

PCT (ng/mL)

7.63 (1.48-24.04)

4.96 (1.07-23.31)

12.85 (4.23-35.52)

ns

CRP (mg/L)

222.15 (131-337.9)

182.5 (131.62-96.24)

249.08 (124-349.55)

ns

Lactate (mmol/L)

2.39 (1.68-3.96)

2.21 (1.62-3.38)

3.17 (1.96-4.56)

0.015

Platelets (x103/µL)

172.5 (106.5-276)

200(143.5-296)

125.65.2-202.5)

0.003

Cholesterol (mg/dL)

119.5 (81.5-153.5)

125.5 (91.75-161)

105 (67.75-135.75)

ns

  1. *Mann-Whitney test; IQR= interquartile range, MR-proADM = Mid-regional pro-adrenomedullin; PCT = Procalcitonin; CRP = C-reactive protein). MR-proADM was the best predictor of 28-day mortality with the largest AUC (0.77; 95% CI: 0.7-0.89), followed by platelets (0.76; 95% CI: 0.67-0.85) and lactate (0.74; 95% CI: 0.64-0.83).