RAGE in 1-hit VILI. Lung wet-to-dry ratios (A) and total protein level (B), cell influx (C), and neutrophil counts (D) in bronchoalveolar lavage fluid of wild-type (WT) and RAGE knockout (KO) mice with healthy lungs ventilated for 5 h with low tidal volumes (LVT ~ 7.5 ml/kg) or high tidal volumes (HVT ~ 15 ml/kg). Non-ventilated mice (C) served as control. Data represent mean (SEM) of n = 6 to 9 mice/group. *p < 0.05, **p < 0.01, and ***p < 0.001.