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Figure 4 | Intensive Care Medicine Experimental

Figure 4

From: The receptor for advanced glycation end products in ventilator-induced lung injury

Figure 4

RAGE in 2-hit VILI. Neutrophil counts (A) and levels of interleukin (IL)-6 (B), keratinocyte-derived chemokine (KC) (C) and tumor necrosis factor (TNF)-α (D) in bronchoalveolar lavage fluid of wild-type (WT) and RAGE knockout (KO) mice in a 2-hit lung injury model of lipopolysaccharide (LPS) exposure followed by mechanical ventilation for 5 h with low tidal volumes (LVT ~ 7.5 ml/kg) or high tidal volumes (HVT ~ 15 ml/kg). LPS-exposed non-ventilated mice (C) served as control. Data represent mean (SEM) of n = 6 to 9 mice/group. *p < 0.05, **p < 0.01, and ***p < 0.001.

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