The receptor for advanced glycation end products in ventilator-induced lung injury

Intensive Care Medicine Experimental

Table 1 Cytokines and chemokines in bronchoalveolar lavage fluid in 1-hit VILI

	C WT	C KO	LV_TWT	LV_TKO	HV_TWT	HV_TKO
IL-6 [ng/ml]	B.D.	B.D.	104.0 (17.0)	101.0 (12.4)	156.1 (15.9)***	142.7 (18.6)
KC [ng/ml]	51.4 (0.7)	B.D.	336.7 (70.0)**	463.4 (123.7)	423.4 (94.0)**	505.9 (59.3)
MIP-2 [ng/ml]	B.D.	B.D.	239.6 (56.5)*	233.2 (35.4)	189.2 (18.4)	216.2 (20.6)
IL-1β [ng/ml]	B.D.	B.D.	69.9 (21.9)*	64.9 (15.9)	57.3 (14.5)*	66.0 (21.3)

Cytokines and chemokines [pg/ml] in bronchoalveolar lavage fluid of wild-type (WT) and RAGE knockout (KO) mice with healthy lungs ventilated for 5 h with low tidal volumes (LV_T ~ 7.5 ml/kg) or high tidal volumes (HV_T ~ 15 ml/kg). Non-ventilated mice (C) served as control. Data represent mean (SEM) of n = 6 to 9 mice/group. *p < 0.05; **p < 0.01; ***p < 0.001 vs controls. B.D., below detection.