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Table 1 Cytokines and chemokines in bronchoalveolar lavage fluid in 1-hit VILI

From: The receptor for advanced glycation end products in ventilator-induced lung injury

  C WT C KO LVTWT LVTKO HVTWT HVTKO
IL-6 [ng/ml] B.D. B.D. 104.0 (17.0) 101.0 (12.4) 156.1 (15.9)*** 142.7 (18.6)
KC [ng/ml] 51.4 (0.7) B.D. 336.7 (70.0)** 463.4 (123.7) 423.4 (94.0)** 505.9 (59.3)
MIP-2 [ng/ml] B.D. B.D. 239.6 (56.5)* 233.2 (35.4) 189.2 (18.4) 216.2 (20.6)
IL-1β [ng/ml] B.D. B.D. 69.9 (21.9)* 64.9 (15.9) 57.3 (14.5)* 66.0 (21.3)
  1. Cytokines and chemokines [pg/ml] in bronchoalveolar lavage fluid of wild-type (WT) and RAGE knockout (KO) mice with healthy lungs ventilated for 5 h with low tidal volumes (LVT ~ 7.5 ml/kg) or high tidal volumes (HVT ~ 15 ml/kg). Non-ventilated mice (C) served as control. Data represent mean (SEM) of n = 6 to 9 mice/group. *p < 0.05; **p < 0.01; ***p < 0.001 vs controls. B.D., below detection.