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Table 2 Cytok ine, chemokine, and endothelial activation markers together with the neuronal destruction marker

From: Brain function in iNOS knock out or iNOS inhibited (l-NIL) mice under endotoxic shock

  NSE IL-6 IL-10 ICAM CXCL-5 Nitrate/nitrite
(ng/ml) (ng/ml) (ng/ml) (ng/ml) (ng/ml) (μmol/l)
Control 10 ± 3 1 ± 0.6 0.2 ± 0.1 84 ± 15 0.3 ± 0.3 120 ± 50
Wt + LPS 14 ± 4 (p = 0.08) 224 ± 81**** 3.6 ± 1.5**** 156 ± 20**** 12 ± 6**** 330 ± 130***
Wt + LPS + l-NIL 13 ± 2 175 ± 82**** 1.8 ± 0.7*, ## 141 ± 12**** 7 ± 2****, ## 150 ± 33
iNOS(−/−) + LPS 14 ± 3 243 ± 32**** 2.6 ± 1.5** 145 ± 11**** 6 ± 1****, ## 41 ± 10
ANOVA ns p < 0.0001 p < 0.0005 p < 0.0001 p < 0.0001 p < 0.0001
  1. Cytokine, chemokine, and endothelial activation markers together with the neuronal destruction marker are given as mean ± SD together with statistical results. In case of a significant ANOVA, the post hoc statistical test results to baseline are given as **p < 0.01, ***p < 0.001, ****p < 0.0001. Statistical significant differences to wt + LPS in the LPS groups are given as ##p < 0.01. ns, not significant.