Brain function in iNOS knock out or iNOS inhibited (l-NIL) mice under endotoxic shock

Intensive Care Medicine Experimental

Table 2 Cytok ine, chemokine, and endothelial activation markers together with the neuronal destruction marker

	NSE	IL-6	IL-10	ICAM	CXCL-5	Nitrate/nitrite
	(ng/ml)	(ng/ml)	(ng/ml)	(ng/ml)	(ng/ml)	(μmol/l)
Control	10 ± 3	1 ± 0.6	0.2 ± 0.1	84 ± 15	0.3 ± 0.3	120 ± 50
Wt + LPS	14 ± 4 (p = 0.08)	224 ± 81****	3.6 ± 1.5****	156 ± 20****	12 ± 6****	330 ± 130***
Wt + LPS + l-NIL	13 ± 2	175 ± 82****	1.8 ± 0.7*^{, ##}	141 ± 12****	7 ± 2****^{, ##}	150 ± 33
iNOS(−/−) + LPS	14 ± 3	243 ± 32****	2.6 ± 1.5**	145 ± 11****	6 ± 1****^{, ##}	41 ± 10
ANOVA	ns	p < 0.0001	p < 0.0005	p < 0.0001	p < 0.0001	p < 0.0001

Cytokine, chemokine, and endothelial activation markers together with the neuronal destruction marker are given as mean ± SD together with statistical results. In case of a significant ANOVA, the post hoc statistical test results to baseline are given as **p < 0.01, ***p < 0.001, ****p < 0.0001. Statistical significant differences to wt + LPS in the LPS groups are given as ^##p < 0.01. ns, not significant.