Table 2 The effect of oleic acid-induced lung injury, and incremental application of PEEP on variables reflecting cardiopulmonary function in six anesthetized, mechanically ventilated pigs

Heart rate (bpm)

81 ± 14

92 ± 12

91 ± 17

94 ± 18

100 ± 14

94 ± 8

NS

Mean blood pressure (mmHg)

93 ± 11

68 ± 4

66 ± 4

67 ± 4

76 ± 6

78 ± 9

<0.001

Core temperature (°C)

35.7 ± 0.5

35.5 ± 0.6

35.6 ± 0.6

35.5 ± 0.6

35.5 ± 0.6

35.5 ± 0.6

NS

Cardiac output (L/min)

3.9 ± 0.6

4.0 ± 0.6

3.7 ± 0.6

3.2 ± 0.5

3.0 ± 0.4

4.1 ± 0.6

<0.001

P_aO₂ (mmHg)

97 ± 17

82 ± 12

119 ± 33

174 ± 32

237 ± 33

76 ± 8

<0.001

P_aCO₂(mmHg)

39 ± 2

51 ± 6

47 ± 4

45 ± 4

44 ± 5

50 ± 6

<0.001

pH_a

7.42 ± 0.02

7.33 ± 0.03

7.35 ± 0.04

7.37 ± 0.03

7.37 ± 0.04

7.34 ± 0.03

<0.001

S_aO₂

94 ± 4

91 ± 4

95 ± 2

97 ± 1

98 ± 0

90 ± 4

<0.001

Ventilator rate (cpm)

17 ± 2

20 ± 2

20 ± 2

20 ± 2

20 ± 2

21 ± 2

<0.001

Tidal volume (ml)

377 ± 25

357 ± 29

370 ± 15

370 ± 15

365 ± 21

365 ± 23

NS

F_IO₂

0.22 ± 0

0.52 ± 0.22

0.52 ± 0.22

0.52 ± 0.20

0.53 ± 0.21

0.62 ± 0.26

NT

Venous admixture (%)

13 ± 14

57 ± 13

45 ± 18

32 ± 19

16 ± 18

65 ± 11

<0.001

C_st (ml/cmH₂O)

33 ± 5

16 ± 3

19 ± 3

22 ± 3

23 ± 2

18 ± 3

<0.001