Macro- and micronutrient disposition in an ex vivo model of extracorporeal membrane oxygenation

Intensive Care Medicine Experimental

Table 3 Linear changes over time in nutrient levels

Nutrient	Units	Mean	Lower	Upper	pvalue
Macronutrients
Glucose*	mmol/L	−0.44	−0.47	−0.41	< 0.001
Total protein	g/L	−0.02	−0.08	0.04	0.54
Total cholesterol	mmol/L	0.00	−0.00	0.00	0.60
Triglycerides	mmol/L	−0.00	−0.02	0.00	0.45
Alanine*	μmol/L	−4.87	−7.78	−1.95	0.008
Arginine*	μmol/L	−19.6	−25.4	−13.83	< 0.001
Citrulline	μmol/L	0.10	0.04	0.15	< 0.003
Cystine*	μmol/L	−0.07	−0.16	0.01	0.12
Glutamate	μmol/L	3.86	3.23	4.48	< 0.001
Glutamine*	μmol/L	−2.34	−3.29	−1.38	< 0.001
Glycine	μmol/L	−0.04	−3.23	3.14	0.97
Histidine	μmol/L	1.14	0.78	1.51	< 0.001
Isoleucine*	μmol/L	−0.61	−1.08	−0.13	0.02
Leucine	μmol/L	2.43	1.69	3.17	< 0.001
Lysine	μmol/L	0.8	0.34	1.410	0.006
Ornithine	μmol/L	20.64	15.42	25.85	< 0.001
Phenylalanine	μmol/L	1.04	0.57	1.51	0.001
Proline	μmol/L	0.24	−0.60	1.08	0.57
Serine	μmol/L	0.32	−0.20	0.83	0.23
Taurine	μmol/L	0.90	0.43	1.37	0.002
Threonine	μmol/L	0.83	0.35	1.31	0.007
Tyrosine	μmol/L	0.62	0.46	0.77	< 0.001
Valine	μmol/L	1.86	1.01	2.71	< 0.001
Trace elements
Copper	μmol/L	−0.00	−0.02	0.02	1
Manganese	nmol/L	−0.20	−0.51	0.1	0.23
Selenium	μmol/L	0.00	−0.00	0.01	0.21
Zinc	μmol/L	0.06	0.04	0.09	< 0.001
Vitamins
Vit A*	nmol/L	−0.01	−0.01	−0.01	< 0.001
Vit C	nmol/L	1.53	1.01	2.06	< 0.001
Vit D	nmol/L	−0.05	−0.22	0.13	0.62
Vit E*	nmol/L	−0.03	−0.04	−0.01	0.003

Using a mixed model with post-parenteral nutrition solution injection plasma nutrient concentrations as the baseline and a random intercept for each circuit. Mean changes and 95% confidence intervals. The estimates in the table are per hour. For example, for alanine, the mean loss in 4.87 units per hour with a 95% confidence interval of −7. 78 to −1.95. Nutrients with significant reductions in concentrations over 24 h are marked in asterisk (*).