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Figure 3 | Intensive Care Medicine Experimental

Figure 3

From: Sepsis-induced acute kidney injury by standardized colon ascendens stent peritonitis in rats - a simple, reproducible animal model

Figure 3

Histology of AKI in a clinically relevant model of sCASP-induced sepsis. HE staining of rat kidney cortex 24 h after sCASP surgery (E), sham surgery (C) or control group (A). Periodic acid Schiff (PAS) staining of rat kidney cortex 24 h after sCASP surgery (F), sham surgery (D) or control group (B). Some of the lesion criteria are exemplified. Therefore, magnifications of some areas are shown on the right (as indicated by the white big arrows). White arrows without heads in (E) point to interstitial edema. White arrowheads in (E) show tubular epithelial cells going to death. Black arrows in (E), (F), and (F′) show vesicles in epithelial cells of the tubules. Black arrowheads in (F) and (F′) show ablation of the tubular epithelium from the basement membrane. For details, see text. (G) shows the total injury score, whilst (H) provides evidence of systemic inflammation by showing different values of interleukin 6 [pg/ml]. *p < 0.05 vs. control, §p < 0.05 vs. sham.

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