Figure 6From: Calcium desensitisation in late polymicrobial sepsis is associated with loss of vasopressor sensitivity in a murine model Attenuated PKC-dependent contraction in septic mouse artery was associated with reduced inhibitory phosphorylation of MLCP. The activity state of MLCP was increased in femoral arteries stimulated with PDBu (5 μM) in 5-day CLP mice relative to those in sham mice (indexed by reduction in the ratio of Thr855 phosphorylated to unphosphorylated MYPT on Western blot analysis). *p < 0.05, n = 8.Back to article page