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Figure 8 | Intensive Care Medicine Experimental

Figure 8

From: Calcium desensitisation in late polymicrobial sepsis is associated with loss of vasopressor sensitivity in a murine model

Figure 8

Vasoconstrictor responses to stimulation with phenylephrine and noradrenaline remained intact in arteries from septic mice. Dose-response curves to stimulation with NA (10−8 to 10−4 M) (A) and PE (10−8 to 10−4 M) (B) were generated using wire myograph-mounted femoral arteries. For both agonists, dose-response curves in 5-day CLP mice (filled circles) and sham mice (hollow circles) did not differ with regard to EC50 or E max (p > 0.05). (n = 7 to 12).

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