Attenuated platelet aggregation in patients with septic shock is independent from the activity state of myosin light chain phosphorylation or a reduction in Rho kinase-dependent inhibition of myosin light chain phosphatase

Intensive Care Medicine Experimental

Table 1 Clinical status at the time of blood sampling

	Septic shock	Non-septic shock
Number	37	40
Age	60.54 ± 13.55	60.5 ± 14.52
Female, n (%)	26 (70)	27 (68)
Smoker, n (%)	12 (32)	8 (20)
APACHE II score^a	24.14 (1.19)	NA
SOFA score^b	9.5 (0.47)	NA
Proven infection, n (%)	26 (70)	NA
Gram-positive	8	NA
Gram-negative	10	NA
Mixed	5	NA
Fungal	3	NA
Mean catecholamine dose (μg/min)	18.7 (2.03)	NA
Platelet count (10⁹/l)	278 (24.3)	261 (12.4)
ICU mortality (%)	10 (27)	0
Hospital mortality, n (%)	16 (43)	2 (5)

Unless otherwise stated, values indicate mean and SEM; p > 0.05 for all comparisons except ICU and hospital mortality, where p < 0.01. ^aAcute physiology and chronic health evaluation (APACHE) II score, a higher value indicates greater admission illness severity. ^bSequential organ failure assessment (SOFA) scores range from 0 to 24 with higher scores indicating more severe organ dysfunction. NA, non-applicable.