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Intensive Care Medicine Experimental
Figure 1 | Intensive Care Medicine Experimental

Figure 1

From: Shape descriptors of the “never resting” microglia in three different acute brain injury models in mice

Figure 1

Lesion characteristics at 24 h after tMCAo, pMCAo, or TBI and placement of acquisition fields. Lesion size distribution is shown at different anteroposterior (AP) coordinates relative to the bregma for tMCAo, pMCAo, or TBI (n = 6) (A). The maximum lesion size for tMCAo is at −0.88 mm from the bregma, for pMCAo at +0.08 mm, and for TBI at −1.84 mm from the bregma. For each injury model, representative sections stained by cresyl violet are shown. The lesion has been sampled by distributing ×40 acquisition fields over the region of interest as depicted in the figure (B) (scale bar = 1 mm). The frame centers at ×40 were distanced 532 μm (tMCAo and pMCAo) or 358 μm (TBI) for horizontally aligned frames and 266 μm for vertically aligned frames, covering 0.2 mm2 total area. For tMCAo and pMCAo, acquisition fields were placed within the lesion core, while for TBI, since part of the lesion core tissue is lost, acquisition fields were positioned at the contusion edge.

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