Serial mean changes in fluids and hemodynamics for HS. vs. raxibacumab animals in study 1. This figure compares the serial mean (±SEM) changes from baseline in fluid in (A), fluid out (B), net fluid (C), pulmonary capillary wedge pressure (PCWP) (D), norepinephrine use (NE) (E), mean arterial blood pressure (MAP) (F), shock index score (G), heart rate (HR) (H), left ventricular ejection fraction (LVEF) (I), central venous pressure (CVP) (J), cardiac index (CI) (K), and systemic vascular resistance (SVR) (L) for animals receiving hemodynamic support alone (HS, fluids and norepinephrine titrated to pulmonary artery wedge pressure and mean arterial blood pressure, respectively) versus HS combined with raxibacumab administered at the start of (HS + mAbT0) or 6 h (HS + mAbT6) or 12 h (HS + mAbT12) after the start of edema toxin challenge in Study 1. Units of measure are shown in each panel (except for shock index score). *p ≤ 0.05, **p < 0.0001.