Serial mean changes in ABG data for HS. vs. raxibacumab animals in study 1. This figure compares the serial mean (±SEM) changes from baseline in pH (A), HCO3
(B), arterial base excess (ABE) (C), lactate (D), PaCO2
(E), and alveolar to arterial oxygen gradient (AaO2) (F) for animals receiving hemodynamic support alone (HS, fluids and norepinephrine titrated to pulmonary artery wedge pressure and mean arterial blood pressure, respectively) versus HS combined with raxibacumab administered at the start of (HS + mAbT0) or 6 h (HS + mAbT6) or 12 h (HS + mAbT12) after the start of edema toxin challenge in Study 1. Units of measure are shown in each panel *p ≤ 0.05, **p < 0.0001.