Partial pressure of oxygen and fraction of inspired oxygen ratio (PaO2/FiO2) measured at the end of the protocol. (A) Series 1 - Early therapy: ANOVA effect of treatment at the end p = 0.007; *p = 0.030 and #p = 0.013 vs vehicle. Vehicle n = 14; ALD n = 11; AHD n = 13. (B) Series 2 - Rescue therapy: §p = 0.043 vs vehicle. Vehicle n = 5; Ang-(1-7) n = 5. Healthy rats (dotted line). Results are expressed as mean ± SD.