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Table 1 Systemic hemodynamics, oxygen transport, and acid-base variables

From: Effects of norepinephrine on tissue perfusion in a sheep model of intra-abdominal hypertension

    Abdominal hypertension
   Basal 60′ 120′
Mean arterial blood pressure (mm Hg) IAH control 83 ± 12 75 ± 10 69 ± 11*
IAH norepinephrine 81 ± 7 73 ± 9 93 ± 11
Sham 76 ± 13 87 ± 14 87 ± 15
Heart rate (beats.min−1) IAH control 177 ± 28 183 ± 51 186 ± 42
IAH norepinephrine 173 ± 26 185 ± 45 209 ± 43
Sham 173 ± 46 174 ± 38 184 ± 30
Cardiac index (mL.min−1.kg−1) IAH control 122 ± 26 121 ± 41 134 ± 55
IAH norepinephrine 96 ± 17 118 ± 42 113 ± 37
Sham 113 ± 18 120 ± 28 127 ± 24
Mean pulmonary pressure (mm Hg) IAH control 16 ± 4 27 ± 6 27 ± 4
IAH norepinephrine 18 ± 7 34 ± 11 35 ± 11
Sham 16 ± 3 18 ± 6* 18 ± 7*
Pulmonary artery occlusion pressure (mm Hg) IAH control 3 ± 2 8 ± 4 8 ± 3
IAH norepinephrine 4 ± 2 11 ± 5 14 ± 6*
Sham 4 ± 2 3 ± 2* 3 ± 2*
Central venous pressure (mm Hg) IAH control 2 ± 2 7 ± 3 6 ± 3
IAH norepinephrine 2 ± 2 9 ± 5 11 ± 6*
Sham 2 ± 1 1 ± 1* 2 ± 2*
Systemic vascular resistance (dynes.s.cm−5) IAH control 3,071 ± 459 2,756 ± 773 2,236 ± 481
IAH norepinephrine 3,138 ± 890 2,433 ± 1,481 2,918 ± 1,401
Sham 2,579 ± 714 2,900 ± 984 2,674 ± 935
Pulmonary vascular resistance (dynes.s.cm−5) IAH control 523 ± 195 774 ± 339 682 ± 251
IAH norepinephrine 541 ± 247 872 ± 661 752 ± 432
Sham 435 ± 199 525 ± 280 471 ± 267
Systemic oxygen transport (mL.min−1.kg−1) IAH control 13.4 ± 3.1 10.2 ± 2.9 10.7 ± 4.6
IAH norepinephrine 10.7 ± 3.0 8.4 ± 3.7 8.1 ± 3.9
Sham 11.2 ± 3.7 10.4 ± 3.2 10.9 ± 3.1
Systemic oxygen consumption (mL.min−1.kg−1) IAH control 6.3 ± 1.1 6.0 ± 1.2 6.4 ± 2.2
IAH norepinephrine 5.3 ± 1.3 5.8 ± 2.3 4.7 ± 2.0
Sham 5.0 ± 2.3 5.1 ± 2.3 5.0 ± 1.9
Arterial pH IAH control 7.39 ± 0.07 7.27 ± 0.06 7.20 ± 0.09
IAH norepinephrine 7.39 ± 0.04 7.22 ± 0.08 7.11 ± 0.15
Sham 7.40 ± 0.06 7.38 ± 0.08* 7.37 ± 0.10*
Arterial PCO2 (mm Hg) IAH control 35 ± 3 39 ± 5 40 ± 6
IAH norepinephrine 35 ± 5 42 ± 3 43 ± 7
Sham 37 ± 4 39 ± 4 38 ± 3
Arterial PO2 (mm Hg) IAH control 79 ± 9 58 ± 13 58 ± 16
IAH norepinephrine 76 ± 9 47 ± 8 55 ± 8
Sham 75 ± 11 67 ± 18 69 ± 16
Arterial base excess (mmol.L−1) IAH control −2 ± 3 −9 ± 3 −12 ± 3
IAH norepinephrine −3 ± 4 −10 ± 5 −15 ± 7
Sham −1 ± 3 −2 ± 4* −3 ± 5*
Arterial anion gap (mmol.L−1) IAH control 12 ± 3 15 ± 5 17 ± 6
IAH norepinephrine 11 ± 2 14 ± 4 16 ± 5
Sham 9 ± 3 9 ± 3* 9 ± 5*
Arterial lactate (mmol.L−1) IAH control 1.9 ± 0.7± 4.0 ± 2.5 6.9 ± 2.8
IAH norepinephrine 2.2 ± 0.5 5.0 ± 2.9 6.9 ± 1.8
Sham 1.9 ± 0.4 1.3 ± 0.6* 2.6 ± 0.6*
  1. *P < 0.05 vs. the other groups.