Table 1 Systemic hemodynamics, oxygen transport, and acid-base variables
From: Effects of norepinephrine on tissue perfusion in a sheep model of intra-abdominal hypertension
Abdominal hypertension | ||||
|---|---|---|---|---|
Basal | 60′ | 120′ | ||
Mean arterial blood pressure (mm Hg) | IAH control | 83 ± 12 | 75 ± 10 | 69 ± 11* |
IAH norepinephrine | 81 ± 7 | 73 ± 9 | 93 ± 11 | |
Sham | 76 ± 13 | 87 ± 14 | 87 ± 15 | |
Heart rate (beats.min−1) | IAH control | 177 ± 28 | 183 ± 51 | 186 ± 42 |
IAH norepinephrine | 173 ± 26 | 185 ± 45 | 209 ± 43 | |
Sham | 173 ± 46 | 174 ± 38 | 184 ± 30 | |
Cardiac index (mL.min−1.kg−1) | IAH control | 122 ± 26 | 121 ± 41 | 134 ± 55 |
IAH norepinephrine | 96 ± 17 | 118 ± 42 | 113 ± 37 | |
Sham | 113 ± 18 | 120 ± 28 | 127 ± 24 | |
Mean pulmonary pressure (mm Hg) | IAH control | 16 ± 4 | 27 ± 6 | 27 ± 4 |
IAH norepinephrine | 18 ± 7 | 34 ± 11 | 35 ± 11 | |
Sham | 16 ± 3 | 18 ± 6* | 18 ± 7* | |
Pulmonary artery occlusion pressure (mm Hg) | IAH control | 3 ± 2 | 8 ± 4 | 8 ± 3 |
IAH norepinephrine | 4 ± 2 | 11 ± 5 | 14 ± 6* | |
Sham | 4 ± 2 | 3 ± 2* | 3 ± 2* | |
Central venous pressure (mm Hg) | IAH control | 2 ± 2 | 7 ± 3 | 6 ± 3 |
IAH norepinephrine | 2 ± 2 | 9 ± 5 | 11 ± 6* | |
Sham | 2 ± 1 | 1 ± 1* | 2 ± 2* | |
Systemic vascular resistance (dynes.s.cm−5) | IAH control | 3,071 ± 459 | 2,756 ± 773 | 2,236 ± 481 |
IAH norepinephrine | 3,138 ± 890 | 2,433 ± 1,481 | 2,918 ± 1,401 | |
Sham | 2,579 ± 714 | 2,900 ± 984 | 2,674 ± 935 | |
Pulmonary vascular resistance (dynes.s.cm−5) | IAH control | 523 ± 195 | 774 ± 339 | 682 ± 251 |
IAH norepinephrine | 541 ± 247 | 872 ± 661 | 752 ± 432 | |
Sham | 435 ± 199 | 525 ± 280 | 471 ± 267 | |
Systemic oxygen transport (mL.min−1.kg−1) | IAH control | 13.4 ± 3.1 | 10.2 ± 2.9 | 10.7 ± 4.6 |
IAH norepinephrine | 10.7 ± 3.0 | 8.4 ± 3.7 | 8.1 ± 3.9 | |
Sham | 11.2 ± 3.7 | 10.4 ± 3.2 | 10.9 ± 3.1 | |
Systemic oxygen consumption (mL.min−1.kg−1) | IAH control | 6.3 ± 1.1 | 6.0 ± 1.2 | 6.4 ± 2.2 |
IAH norepinephrine | 5.3 ± 1.3 | 5.8 ± 2.3 | 4.7 ± 2.0 | |
Sham | 5.0 ± 2.3 | 5.1 ± 2.3 | 5.0 ± 1.9 | |
Arterial pH | IAH control | 7.39 ± 0.07 | 7.27 ± 0.06 | 7.20 ± 0.09 |
IAH norepinephrine | 7.39 ± 0.04 | 7.22 ± 0.08 | 7.11 ± 0.15 | |
Sham | 7.40 ± 0.06 | 7.38 ± 0.08* | 7.37 ± 0.10* | |
Arterial PCO2 (mm Hg) | IAH control | 35 ± 3 | 39 ± 5 | 40 ± 6 |
IAH norepinephrine | 35 ± 5 | 42 ± 3 | 43 ± 7 | |
Sham | 37 ± 4 | 39 ± 4 | 38 ± 3 | |
Arterial PO2 (mm Hg) | IAH control | 79 ± 9 | 58 ± 13 | 58 ± 16 |
IAH norepinephrine | 76 ± 9 | 47 ± 8 | 55 ± 8 | |
Sham | 75 ± 11 | 67 ± 18 | 69 ± 16 | |
Arterial base excess (mmol.L−1) | IAH control | −2 ± 3 | −9 ± 3 | −12 ± 3 |
IAH norepinephrine | −3 ± 4 | −10 ± 5 | −15 ± 7 | |
Sham | −1 ± 3 | −2 ± 4* | −3 ± 5* | |
Arterial anion gap (mmol.L−1) | IAH control | 12 ± 3 | 15 ± 5 | 17 ± 6 |
IAH norepinephrine | 11 ± 2 | 14 ± 4 | 16 ± 5 | |
Sham | 9 ± 3 | 9 ± 3* | 9 ± 5* | |
Arterial lactate (mmol.L−1) | IAH control | 1.9 ± 0.7± | 4.0 ± 2.5 | 6.9 ± 2.8 |
IAH norepinephrine | 2.2 ± 0.5 | 5.0 ± 2.9 | 6.9 ± 1.8 | |
Sham | 1.9 ± 0.4 | 1.3 ± 0.6* | 2.6 ± 0.6* | |