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Figure 1 | Intensive Care Medicine Experimental

Figure 1

From: Why do they die? Comparison of selected aspects of organ injury and dysfunction in mice surviving and dying in acute abdominal sepsis

Figure 1

Survival curve and outcome prediction based on body temperature. (A) Seven-day mortality in 4-week-old OF-1 mice subjected to CLP-Only and daily low-volume blood sampling for days 1 to 5 post-CLP. (B) Experimental setup for prospective BT-based outcome prediction. A septic mouse was predicted to die (P-DIE) whenever its BT dropped below 28°C within days 1 to 5 post-CLP. Upon detection, each P-DIE mouse was always sacrificed with a matching predicted to survive (P-SUR) mouse (i.e. with BT ≥35°C). (C) ROC curve and corresponding area under the curve (AUC) for the prediction of outcome based on BT in acute CLP sepsis (days 1 to 5 post-CLP). BT ≤28°C identified dying mice with 94% specificity, while a BT ≥35°C identified surviving mice with 100% specificity. The BT cutoffs for outcome prediction utilized in this study were predetermined based on the internal BT measurement database compiled in previous studies.

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