Why do they die? Comparison of selected aspects of organ injury and dysfunction in mice surviving and dying in acute abdominal sepsis

Intensive Care Medicine Experimental

Table 2 Capacity to predict outcome in acute CLP sepsis

Parameter	AUC	Cutoff	Specificity (%)	Sensitivity (%)
Urea	0.85	77 mg/dl	100	40
Glucose	0.78	30 U/l	100	25
LDH	0.68	1,320 U/l	100	17
ALT	0.68	365 U/l	100	7

CLP-Only mice were never sacrificed but sampled daily for blood between days 1 to 5 post-CLP and followed for 28 days. For ROC analysis, parameter values recorded within 24 h of death (occurring anytime between days 1 and 5 post-CLP) and from mice that lived until day 28 post-CLP were used. Specificity was set to 100% to identify only mice predicted to die without committing the type I error (i.e. an erroneous inclusion of P-SUR animals). ROC calculation was based on: n = 42 for mice that died within days 1 to 5 and n = 40 for mice that survived until day 28 post-CLP.