A randomized clinical trial of ascorbic acid in open abdominal aortic aneurysm repair

Intensive Care Medicine Experimental

Table 2 Comparison of biomarkers in ascorbic acid and placebo groups pre- and post-operatively

	Pre operative parameters			Post operative parameters
	Placebo group	Ascorbate group	p-value	Placebo group	Ascorbate group	p-value
	n = 18	n = 13		n = 18	n = 13
	Mean (SD),	Mean (SD),		Mean (SD),	Mean (SD),
	Median (IQR)	Median (IQR)		Median (IQR)	Median (IQR)
Endothelial function
vWF (% Control)	141 (61)	139 (60)	0.92	158 (78)	169 (65)	0.68
EDV (%)	3.5 (1.8, 5.3)	3.0 (1.5, 5.5)	0.42	6.0 (2.5, 8.5)	4.0 (2.0, 6.0)	0.32
Vd/Vt	0.56 (0.06)	0.54 (0.05)	0.53	0.56 (0.06)	0.54 (0.06)	0.74
Systemic and pulmonary inflammatory mediators
Serum hsCRP (mgL⁻¹)	2.14 (0.97, 5.75)	1.83 (1.15, 4.49)	0.95	2.85 (1.45, 4.63)	1.96 (1.13, 4.23)	0.27
Arterial pH	7.38 (0.04)	7.40 (0.05)	0.43	7.32 (0.08)	7.29 (0.06)	0.20
Pulmonary function
PaO₂:FiO₂ ratio (kPa)	59.6 (47.8, 81.1)	59.6 (46.5, 97.7)	0.44	45.3 (28.3, 49.4)	42.5 (32.7, 51.4)	0.79

SD, Standard Deviation, IQR, Interquartile Range, EDV, Endothelium-dependent vasodilatation, vWF, von Willebrand Factor, Vd/Vt, Pulmonary Deadspace Fraction, EBC, Exhaled Breath Condensate, CRP, C Reactive Protein.