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Table 2 Comparison of biomarkers in ascorbic acid and placebo groups pre- and post-operatively

From: A randomized clinical trial of ascorbic acid in open abdominal aortic aneurysm repair

  Pre operative parameters Post operative parameters
  Placebo group Ascorbate group p-value Placebo group Ascorbate group p-value
n = 18 n = 13   n = 18 n = 13  
Mean (SD), Mean (SD),   Mean (SD), Mean (SD),  
Median (IQR) Median (IQR)   Median (IQR) Median (IQR)  
Endothelial function      
vWF (% Control) 141 (61) 139 (60) 0.92 158 (78) 169 (65) 0.68
EDV (%) 3.5 (1.8, 5.3) 3.0 (1.5, 5.5) 0.42 6.0 (2.5, 8.5) 4.0 (2.0, 6.0) 0.32
Vd/Vt 0.56 (0.06) 0.54 (0.05) 0.53 0.56 (0.06) 0.54 (0.06) 0.74
Systemic and pulmonary inflammatory mediators    
Serum hsCRP (mgL−1) 2.14 (0.97, 5.75) 1.83 (1.15, 4.49) 0.95 2.85 (1.45, 4.63) 1.96 (1.13, 4.23) 0.27
Arterial pH 7.38 (0.04) 7.40 (0.05) 0.43 7.32 (0.08) 7.29 (0.06) 0.20
Pulmonary function      
PaO2:FiO2 ratio (kPa) 59.6 (47.8, 81.1) 59.6 (46.5, 97.7) 0.44 45.3 (28.3, 49.4) 42.5 (32.7, 51.4) 0.79
  1. SD, Standard Deviation, IQR, Interquartile Range, EDV, Endothelium-dependent vasodilatation, vWF, von Willebrand Factor, Vd/Vt, Pulmonary Deadspace Fraction, EBC, Exhaled Breath Condensate, CRP, C Reactive Protein.