Fig. 4
From: Critical illness-induced bone loss is related to deficient autophagy and histone hypomethylation
Induction of autophagy restores bone loss in critically ill rabbits. (a) After 3 days, there was a trend (p = 0.2) for a reduction in number of trabeculae (b) and a significant reduction in trabecular area (c) in critically ill rabbits compared to controls. Similarly, the cortical area (d) cortical bone mineral content (BMC) (e) and strength strain index (SSI) (f) was significantly reduced. Critically ill rabbits treated with rapamycin displayed a significantly higher number of trabeculae, cortical area, and SSI compared to untreated sick rabbits (p < 0.05; n = 6 per group)